The intersection of innovation and obesity presents a significant opportunity for businesses to address a pressing public health challenge while capitalizing on a growing market demand. This abstract explores the potential for businesses, both existing and new, to innovate within sectors such as food, healthcare, technology, and education to promote healthier lifestyles and combat obesity. With the obesity market estimated at $80 billion annually, entrepreneurs, healthcare providers, and technology developers have ample room for growth and innovation. Existing businesses can reformulate products, offer new services, and advocate for supportive policies, while new ventures can enter the market with innovative solutions targeting obesity-related services and products. Moreover, the DACMAR (Disrupt, Adopt, Collaborate, Manage, Adapt, and Resource) framework provides a structured approach for innovators to navigate the complexities of obesity management. Through the DACMAR framework, stakeholders can drive meaningful progress and innovation in addressing obesity. This framework emphasizes the importance of challenging the status quo, fostering partnerships, effective resource management, and dynamic adaptation to changing circumstances. Similarly, by applying the DACMAR framework's principles, investors can systematically rank different innovations in the obesity domain, ensuring market-readiness, identify go-to-market gaps and align investments with investors’ strategic objectives. This enables objective de-risking to improve investment returns. Furthermore, effective leadership is crucial in driving innovation and change, particularly in complex issues like obesity. Various leadership styles, including transformational, innovative, collaborative, servant, adaptive, and strategic, play essential roles in shaping the direction and impact of obesity prevention and treatment efforts. By leveraging diverse leadership approaches, stakeholders can work together to develop innovative solutions that improve outcomes for individuals and communities affected by obesity. Keywords: obesity, innovation, leadership, business