Gender equality is a central human aspect of the Sustainable Development Goals. Among its multiple and complex issues, this research highlights gender-based violence as a domain that affects women’s empowerment and the guarantees of an effective equality on numerous levels. To address such a complex structure, which perpetuates inequalities between men and women, generating multiple effects and jeopardising social changes, social design can provide contributions on cultural and social levels. To achieve social systemic changes, one needs to activate profound cultural transformations. Thus, how can we change culture without rejecting the need to empower women and promote equality? The Montréal Design Declaration (2017) recognised social design’s potential to achieve the Sustainable Development Goals (SDG), to contribute to global challenges, and to accept a calling for stakeholders’ integration and agency promotion. This review explores how social design can provide contributions with regard to SDG5 and gender-based violence, presenting relevant domains that actively contribute to cultural transformation to address interventions in this systemic phenomenon.