2020
DOI: 10.1016/j.bbamcr.2020.118781
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Leading the invasion: The role of Cathepsin S in the tumour microenvironment

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Cited by 32 publications
(28 citation statements)
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“…The expression and activity of these cathepsins is generally upregulated in (chronic) inflammation and in cancers. Consequently, they are overexpressed in tumors, prominently for CatB and CatS, including in follicular lymphoma, gastric, colon, brain, breast, and pancreatic cancer [1,3,6]. Overall, most but not all of these cathepsin-mediated mechanisms result in enhanced ECM turnover and angiogenesis, clearing the way for tumor expansion, securing the cancers' nutrient supply, and, most notably, in suppressing the T-cell induced anti-cancer immune response that is located in the TME.…”
Section: Cysteine Cathepsins In Tumor Progressionmentioning
confidence: 99%
“…The expression and activity of these cathepsins is generally upregulated in (chronic) inflammation and in cancers. Consequently, they are overexpressed in tumors, prominently for CatB and CatS, including in follicular lymphoma, gastric, colon, brain, breast, and pancreatic cancer [1,3,6]. Overall, most but not all of these cathepsin-mediated mechanisms result in enhanced ECM turnover and angiogenesis, clearing the way for tumor expansion, securing the cancers' nutrient supply, and, most notably, in suppressing the T-cell induced anti-cancer immune response that is located in the TME.…”
Section: Cysteine Cathepsins In Tumor Progressionmentioning
confidence: 99%
“…Cathepsin S, which belongs to the cysteine proteinase family (2), is one of the most potent mammalian elastases that can degrade many extracellular elements, such as elastin, fibronectin, laminin, and collagens (3). Previous studies have revealed that cathepsin S plays a critical role in various diseases, including atherosclerosis (4), abdominal aortic aneurysm (5), cancer (6), obesity (7) and type 2 diabetes (8). Liu et al reported that there is a significant increase of circulating cathepsin S level in both diabetes and atherosclerosis (9).…”
Section: Introductionmentioning
confidence: 99%
“…It highlighted the potential of the α-ketoamide-based highly selective cathepsin S inhibitor RJW-58 in the suppression of cervical cancer cell migration and invasion of cervical cancer cells [ 204 ]. Cathepsin S, a lysosomal cysteine protease, has been reported to be associated with the degradation of the extracellular matrix, thus promoting cell migration and invasion [ 205 ]. Results of immunoprecipitation assays demonstrated that cathepsin S interacted with STIM1, which was reversed by RNAi-mediated silencing and enzymatic inhibition of cathepsin S. Analyses of confocal microscopic and super-resolution imaging indicated that cathepsin S inhibition led to STIM1 puncta accumulation in the ER and interrupted the STIM1-EB1 interaction, a critical step for STIM1 trafficking towards the cell periphery.…”
Section: Intracellular Ca 2+ Homeostasis and Store-operated Ca 2+ Entry (Soce)mentioning
confidence: 99%