Leaf alkaloids of Rauwolfia caffra

Relativistic Force Field: Parametric Computations of Proton–Proton Coupling Constants in 1H NMR Spectra

“…The proton coupling constants for alkaloid macrocaffrine were predicted with rmsd = 0.19 Hz and mue = 0.34 Hz, Figure c, by fitting two major conformers, 55.6–44.4%. There was almost 10% difference in the conformer content predicted by DFT energy.…”

Recent Advances in the Synthesis of β-Carboline Alkaloids

“…The new method was also applied for the synthesis of isoeudistomin U alkaloid (12) starting from tryptamine (108) and indole-3-carboxylic acid (111) Gaikwad et al have developed an iodine-mediated metal-free protocol for the chemoselective dehydrogenation and aromatization of THβCs into DHβCs and β-carbolines in the presence of H2O2 as the oxidant in DMSO (Scheme 9) [122]. The method was applicable not only for the preparation of variously substituted β-carbolines but also for that of bioactive natural products eudistomin U (10), harmalan (13), isoeudistomin M (14), norharman (1), harman (15) and kumujian C (16). The plausible reaction mechanism of the dearomatization protocol was also presented, which starts with a N-iodination followed by an N-dehydroiodination of THβCs 112 and 113, respectively.…”

“…The comprehensive demonstration of recent advances in the synthesis of naturally occurring β-carbolines, including both simple β-carbolines (Chapter 2 of this review) and fused ring systems containing this framework (see Figure 1 and Chapter 3 of this review), is discussed with a special emphasis on the innovative framework construction steps. Noctiluca milaris [10] Strychnos johnsonii [11] Lycoris longituba [12] Selaginella delicatula [13] Trichosanthes kirilowii Maxim [14] Rauwolfia caffra [15] Didemnum sp [16] MAO Cnemidocarpa stolonifera [20] apoptosis in PC3 human prostate cancer cell line [20] 8: Eudistoma olivaceum [21] 9: Eudistoma olivaceum [22] 10: Lissoclinum fragile [23] 11: Eudistoma olivaceum [24] 12: analogues of natural products 13: soybean [28] Flindersia laevicarpa [29] 14: analogues of natural products 15: Flindersia Caevicarpa [29] 16: Picrasma quassioides [30] 13: anti-neuroin-flammatory activities [28] 14: n.a. 15: vasorelaxant effect [31] binding affinity to imidazoline I2B receptors [32] 16: cytotoxic activity [33] AMP phosphodiesterase inhibitor [34] anti-inflammatory agent [35,36] trigonostemine [37] 17, 18, 19: Trigonostemone filipes [38] 20: Malassezia furfur [39] Paracoccus marine bacteria [40] Dichotomomyces cejpii [41] 21: Hyrtio erectus [42] Alocasia macrorrhiza [43] 17, 18, 19: cytotoxic activity [44] 20: antiproliferative activity [45] anticancer activity [46,47] 21: antiproliferative activity…”

Alkaloid Distribution in Some African Rauvolfia Species

“…R. oreogiton MARKGRAF [1,2], R. volkensii STAPF [3][4][5], R. caffra SOND. [6][7][8][9], R. macrophylla STAPF [10][11][12], R. mannii STAPF [13][14], R. obscura K. SCHUM [15][16][17][18], R. rosea K. SCHUM [13], R. cumminsii STAPF [19][20][21][22], R. mombasiana STAPF [23][24][25] and R. vomitoria AFZ. [26][27][28][29].…”