Prevailing and exacerbating impacts of climate change call for robust and resilient humanitarian supply chains (HSCs). To that end, intelligent technologies that brought about the Industry 4.0 (I4.0) revolution, such as the Internet of Things, blockchain, and artificial intelligence, may tremendously impact the optimal design and effective management of HSCs. In this paper, we conduct a systematic literature network analysis and identify trends in I4.0 and HSCs. We posit the need to instill into current HSC efforts the quadruple bottom-line (cultural, economic, environmental, and social) pillars of sustainability and define a Sustainable Humanitarian Supply Chain (SHSC). Based on the extant literature and ongoing practice, we highlight how I4.0 technologies can aid SHSC stages from disaster risk assessment to preparedness to response to relief. The complex nature of SHSCs requires a holistic and multidisciplinary approach and collaboration by scholars, policymakers, and industry practitioners to pool solution resources. We offer future research venues in this fledgling but life-saving scientific discipline. SHSCs can be empowered with I4.0 technologies, a much needed direction in our climate-changed world.