The seismicity rate in the Delaware Basin, located in western Texas and southeastern New Mexico, has increased by orders of magnitude within the past~5 years. While no seismicity was reported in the southern Delaware Basin during 1980-2014, 37 earthquakes with M > 3 occurred in this area during 2015-2018. We generated an improved catalog of~37,000 earthquakes in this region during 2009-2018 by applying multistation template matching at both regional and local stations using all earthquakes in the Advanced National Seismic System (ANSS) and TexNet catalogs. We found that the vast majority of the seismicity is most likely associated with wastewater disposal, while at least~5% of the seismicity was induced directly by hydraulic fracturing. We inferred far-field effects of wastewater disposal inducing earthquakes over distances >25 km. The spatial limits of seismicity correlate with geologic structures that include the Central Platform and Grisham Fault, suggesting hydrologic compartmentalization by low-permeability boundaries. Given that the seismicity rate increased throughout the duration of the study, if industry operations continue unaltered, it is likely that both the seismicity rate and number of M > 3 earthquakes may continue to increase in the future.