This research aims to model the processes through which manufacturing firms can increase the effectiveness of lean manufacturing practices. To achieve its objective this research benefits from the interactive structural modelling technique to first capture the opinions of lean experts and further map the interrelationships between determents of lean manufacturing effectiveness. Findings revealed that employees empowerment, employees involvement, implementation cost, teamwork, managerial leadership and support, awareness of latest lean information and information technology are key determinants of lean manufacturing effectiveness. Findings explain that the precedence relationships between the determining factors identified, and the order of their implementation is crucial to the achievement of highest degrees of lean manufacturing effectiveness. Utility of the proposed interpretive structural modelling methodology imposing order, direction and significance of the relationships among elements of lean manufacturing effectiveness are expected to offer considerable value to the decision makers and lean practitioners.