Learning about language and speech from Deep Brain Stimulation

Klostermann, Fabian; Krugel, Lea K.; Wahl, Michael

doi:10.1016/j.jneuroling.2011.07.005

Cited by 6 publications

(3 citation statements)

References 122 publications

(155 reference statements)

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“…Deep Brain Stimulation (DBS) has become an established therapeutic option for advanced PD with motor fluctuations that are refractory to medical treatment (Kleiner-Fisman et al, 2006;Klostermann, Krugel, & Wahl, 2012). At present, in most centers performing DBS, the subthalamic nucleus (STN) is the target of choice, as high-frequency stimulation in this nucleus improves all cardinal motor symptoms of PD, allowing a reduction of dopaminergic antiparkinson drug treatment (Fasano, Daniele, & Albanese, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Although the working mechanism of DBS is still unclear, DBS is presumed to override the oscillatory patterns of the disrupted networks (Benabid et al, 1996;McIntyre & Hahn, 2010). The effect of STN stimulation on language variables is not as straightforward as on motor symptoms (Klostermann et al, 2012). Whelan, Murdoch, Theodoros, Hall, and Silburn (2003) were among the first to assess the effect of STN stimulation on different high-level language functions with a large assessment battery.…”

Section: Introductionmentioning

confidence: 99%

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Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

et al. 2015

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“…8 Subthalamic local field potentials were also related to speech articulation. 9 Subthalamic stimulation studies demonstrated improvement, [10][11][12] exacerbation, 13,14 or mixed effects on speech-related signs. [15][16][17] The STN is involved in timing at several levels, from multiple seconds 18 to milliseconds.…”

mentioning

confidence: 98%

Impaired Timing of Speech-Related Neurons in the Subthalamic Nucleus of Parkinson Disease Patients Suffering Speech Disorders

Tankus¹,

Lustig²,

Fried³

et al. 2021

Neurosurg.

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BACKGROUND Our previous study found degradation to subthalamic neuronal encoding of speech features in Parkinson disease (PD) patients suffering from speech disorders. OBJECTIVE To find how timing of speech-related neuronal firing changes in PD patients with speech disorders compared to PD patients without speech disorders. METHODS During the implantation of deep brain stimulator (DBS), we recorded the activity of single neurons in the subthalamic nucleus (STN) of 18 neurosurgical patients with PD while they articulated, listened to, or imagined articulation of 5 vowel sounds, each following a beep. We compared subthalamic activity of PD patients with (n = 10) vs without speech disorders. RESULTS In this comparison, patients with speech disorders had longer reaction times and shorter lengths of articulation. Their speech-related neuronal activity preceding speech onset (planning) was delayed relative to the beep, but the time between this activity and the emission of speech sound was similar. Notwithstanding, speech-related neuronal activity following the onset of speech (feedback) was delayed when computed relative to the onset. Only in these patients was the time lag of planning neurons significantly correlated with the reaction time. Neuronal activity in patients with speech disorders was delayed during imagined articulation of vowel sounds but earlier during speech perception. CONCLUSION Our findings indicate that longer reaction times in patients with speech disorders are due to STN or earlier activity of the speech control network. This is a first step in locating the source(s) of PD delays within this network and is therefore of utmost importance for future treatment of speech disorders.

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Thalamic aphasia associated with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes: A case report

Sakata

Nakamura

Ichinose

et al. 2022

Brain and Development

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Learning about language and speech from Deep Brain Stimulation

Cited by 6 publications

References 122 publications

Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

Impaired Timing of Speech-Related Neurons in the Subthalamic Nucleus of Parkinson Disease Patients Suffering Speech Disorders

Thalamic aphasia associated with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes: A case report

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