Learning and Behaviour Problems Associated With Theophylline Therapy

Furukawa, C.T.; Shapiro, G.G.; DuHamel, Thomas R.; Weimer, Linda A.; Pierson, W.E.; Bierman, C. Warren

doi:10.1016/s0140-6736(84)91010-9

Cited by 44 publications

(9 citation statements)

References 6 publications

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“…There may also be increased acid secretion, gastrooesophageal reflux and diuresis. There has recently been concern that theophylline, even at therapeutic concentrations, may lead to behavioural disturbance and learning difficulties in school children [142][143][144], although a carefully designed study could not confirm this [145]. At high concentrations, convulsions and cardiac arrhythmias may occur, and there is concern that intravenous aminophylline administered in the emergency room may be a contributory factor to the deaths of some patients with severe asthma [124].…”

Section: Side-effectsmentioning

confidence: 99%

Theophylline in the management of asthma: time for reappraisal?

Barnes¹,

Pauwels²

1994

Eur Respir J

250

107

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T Th he eo op ph hy yl ll li in ne e i in n t th he e m ma an na ag ge em me en nt t o of f a as st th hm ma a: : t ti im me e f fo or r r re ea ap pp pr ra ai is sa al l? ?P.J. Barnes*, R.A. Pauwels** Theophylline is now considered to be a bronchodilator, but it is increasingly recognized that theophylline has other anti-asthma activities, which may be more important. Theophylline, even at low plasma concentrations, inhibits the late asthmatic reaction following allergen challenge. These clinical pharmacological observations are substantiated by experimental animal and in vitro data showing that theophylline has several anti-inflammatory activities relevant to asthma. These include the inhibition of cytokine synthesis and release, the inhibition of inflammatory cell activation and microvascular leakage, and the prevention of airway hyperresponsiveness induced by airway inflammation. Theophylline appears to have immunomodulatory effects, even at relatively low plasma concentrations.Based on these considerations, theophylline can be regarded as a useful alternative to other anti-inflammatory drugs for the chronic treatment of mild to moderate asthma. Theophylline should be used at lower doses to achieve plasma concentrations of 5-10 mg·l -1 , which will avoid the risk of side-effects.Further studies are required to evaluate the role of low-dose theophylline as an adjunct to low-dose inhaled steroids in the management of chronic asthma. It may now be appropriate to re-evaluate the role of theophylline in asthma management.

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Section: Side-effectsmentioning

confidence: 99%

Theophylline in the management of asthma: time for reappraisal?

Barnes¹,

Pauwels²

1994

Eur Respir J

250

107

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“…Subjects were 26 teachers from an elementary school (grades [1][2][3][4][5][6][7][8] and 42 from high school (grades 9-12). The teachers came from two schools located in the central area of Israel (city of Holon).…”

Section: Methodsmentioning

confidence: 99%

Teachers' Knowledge About Asthma: Assessment, Correlates, and Sources

Brook¹,

Shiloh²

1994

Pediatric Asthma, Allergy & Immunology

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Sixty-eight teachers participated in a study aimed to assess their knowledge about asthma. Findings show that teachers have an inadequate basic level of knowledge of many issues re¬ lated to asthma, including school activities permitted for asthmatic children. The considerable variance of asthma knowledge among teachers related to the following areas: age (younger teachers had better knowledge), personal experience with an asthmatic child, involvement in health education, and reading newspapers and journal articles on health issues. Level of edu¬ cation, classes taught, and being a homeroom teacher were not related to their knowledge about asthma. For the benefit of the asthmatic pupil, it is recommended that a school health program be developed that will deal with the general knowledge of bronchial asthma, includ¬ ing its realistic limitations and modes of coping for the school pupil.

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“…And, when theophylline treatment was discontinued with a group of children, they did better on measures of attention, concentration, and/or memory (Furakawa et al, 1984). Teachers have also been able to pick out the children who were receiving this medication even though parent evaluations and a battery of psychological tests did not (Rachelefsky et al, 1986).…”

Section: Can Allergy Medications Adversely Affect School Performance mentioning

confidence: 99%

Allergies and Learning/Behavioral Disorders

McLoughlin

Nall

1994

Intervention in School and Clinic

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How allergies affect school learning and behavior---and how to help Every fall and spring many teachers notice an outburst of coughmg, sneezing, wheezing, and nose blowing in their classrooms. Afflicted students E are rubbing itchy and bloodshot eyes, scratchmg rashes, and complaining of stomachaches and headaches. They are listless and generally miserable. Yes, you guessed it; it is allergy season! Besides the additional noise and movement in the classroom, teachers are concerned about other things. They question whether this is a temporary condition, and whether they should call parents about it. They sometimes wonder if the sleepy or hyperactive child is taking too much medication. Allergy outbreaks could not come at a worse time than the beginning of the school year, when the student's full attention is particularly crucial, or the end of the school year, when the student's best performance is required on final examinations.

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Learning and Behaviour Problems Associated With Theophylline Therapy

Cited by 44 publications

References 6 publications

Theophylline in the management of asthma: time for reappraisal?

Theophylline in the management of asthma: time for reappraisal?

Teachers' Knowledge About Asthma: Assessment, Correlates, and Sources

Allergies and Learning/Behavioral Disorders

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