Learning and Nicotine Interact to Increase CREB Phosphorylation at the jnk1 Promoter in the Hippocampus

Kenney, Justin W.; Poole, Rachel L.; Adoff, Michael D.; Logue, Sheree F.; Gould, Thomas J.

doi:10.1371/journal.pone.0039939

Cited by 27 publications

(22 citation statements)

References 70 publications

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“…ChIP was performed using a previously published protocol (Kenney et al 2012). Thirty minutes after infusion with vehicle or E 2 , young (n ¼ 15) and middle-aged mice (n ¼ 13) were cervically dislocated, and the dorsal hippocampus was rapidly dissected, flash frozen, and stored at 280˚C until use.…”

Section: Chromatin Immunoprecipitation (Chip)mentioning

confidence: 99%

17β-Estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice

et al. 2014

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Histone acetylation is essential for hippocampal memory formation in young adult rodents. Although dysfunctional histone acetylation has been associated with age-related memory decline in male rodents, little is known about whether histone acetylation is altered by aging in female rodents. In young female mice, the ability of 17b-estradiol (E 2 ) to enhance object recognition memory consolidation requires histone H3 acetylation in the dorsal hippocampus. However, the extent to which histone acetylation is regulated by E 2 in middle-aged females is unknown. The mnemonic benefits of E 2 in aging females appear to be greatest in middle age, and so pinpointing the molecular mechanisms through which E 2 enhances memory at this age could lead to the development of safer and more effective treatments for maintaining memory function without the side effects of current therapies. Here, we show that dorsal hippocampal infusion of E 2 rapidly enhanced object recognition and spatial memory, and increased histone H3 acetylation in the dorsal hippocampus, while also significantly reducing levels of histone deacetylase (HDAC2 and HDAC3) proteins. E 2 specifically increased histone H3 acetylation at Bdnf promoters pII and pIV in the dorsal hippocampus of both young and middle-aged mice, despite age-related decreases in pI and pIV acetylation. Furthermore, levels of mature BDNF and pro-BDNF proteins in the dorsal hippocampus were increased by E 2 in middle-aged females. Together, these data suggest that the middle-aged female dorsal hippocampus remains epigenetically responsive to E 2 , and that E 2 may enhance memory in middle-aged females via epigenetic regulation of Bdnf.

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Section: Chromatin Immunoprecipitation (Chip)mentioning

confidence: 99%

17β-Estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice

et al. 2014

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“…The knockout of these subunits prevents this enhancement, as does the co-administration of high-affinity nicotinic antagonists with nicotine (Davis, Kenney, & Gould, 2007). Additionally, these acute enhancing effects appear to be downstream of the activation of the intra-cellular signaling kinases ERK and JNK (Kenney, Florian, Portugal, Abel, & Gould, 2010a; Kenney, Poole, Adoff, Logue, & Gould, 2012; Raybuck & Gould, 2007). Further isolating the acute effects of nicotine, infusion directly into the dorsal hippocampus is sufficient to enhance context or trace fear conditioning (Davis et al, 2007; Raybuck & Gould, 2010), while the infusion of a high-affinity antagonist into the hippocampus prevents the enhancing effects of systemic nicotine (Davis et al, 2007).…”

Section: Nicotine and Fear Conditioningmentioning

confidence: 99%

Substance abuse, memory, and post-traumatic stress disorder

Tipps

Raybuck

Lattal

2014

Neurobiology of Learning and Memory

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A large body of literature demonstrates the effects of abused substances on memory. These effects differ depending on the drug, the pattern of delivery (acute or chronic), and the drug state at the time of learning or assessment. Substance use disorders involving these drugs are often comorbid with anxiety disorders, such as post-traumatic stress disorder (PTSD). When the cognitive effects of these drugs are considered in the context of the treatment of these disorders, it becomes clear that these drugs may play a deleterious role in the development, maintenance, and treatment of PTSD. In this review, we examine the literature evaluating the cognitive effects of three commonly abused drugs: nicotine, cocaine, and alcohol. These three drugs operate through both common and distinct neurobiological mechanisms and alter learning and memory in multiple ways. We consider how the cognitive and affective effects of these drugs interact with the acquisition, consolidation, and extinction of learned fear, and we discuss the potential impediments that substance abuse creates for the treatment of PTSD.

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“…S2) is a cellular transcription factor that plays a major role in c-AMP and calcium mediated signaling pathway (Kenney et al, 2012). It is connected by twenty-nine different species across the pathway.…”

Section: Biological Relevance Of Hubsmentioning

confidence: 99%

A Comprehensive Metabolic Modeling of Thyroid Pathway in Relation to Thyroid Pathophysiology and Therapeutics

Gupta

Singh

Shukla

et al. 2013

OMICS: A Journal of Integrative Biology

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The thyroid pathway represents a complex interaction of different glands for thyroid hormone synthesis. Thyrotropin releasing hormone is synthesized in the hypothalamus and regulates thyrotropin stimulating hormone gene expression in the pituitary gland. In order to understand the complexity of the thyroid pathways, and using experimental data retrieved from the biomedical literature (e.g., NCBI, HuGE Navigator, Protein Data Bank, and KEGG), we constructed a metabolic map of the thyroid hormone pathway at a molecular level and analyzed it topologically. A total of five hub nodes were predicted in regards to the transcription thyroid receptor (TR), cAMP response element-binding protein (CREB), signal transducer and activator of transcription 3 (STAT 3), nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB), and activator protein 1 (AP-1) as being potentially important in study of thyroid disorders and as novel putative therapeutic drug targets. Notably, the thyroid receptor is a highly connected hub node and currently used as a therapeutic target in hypothyroidism. Our analysis represents the first comprehensive description of the thyroid pathway, which pertains to understanding the function of the protein and gene interaction networks. The findings from this study are therefore informative for pathophysiology and rational therapeutics of thyroid disorders.

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Learning and Nicotine Interact to Increase CREB Phosphorylation at the jnk1 Promoter in the Hippocampus

Cited by 27 publications

References 70 publications

17β-Estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice

17β-Estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice

Substance abuse, memory, and post-traumatic stress disorder

A Comprehensive Metabolic Modeling of Thyroid Pathway in Relation to Thyroid Pathophysiology and Therapeutics

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