Learning-dependent neuronal activity in the premotor cortex: activity during the acquisition of conditional motor associations

Mitz, A. R.; Godschalk, M.; Wise, Steven P.

doi:10.1523/jneurosci.11-06-01855.1991

Cited by 339 publications

(201 citation statements)

References 63 publications

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“…6 shows population averages for IS-on period, but plotted over the entire learning period rather than divided into early, middle, and late phases of learning. In accord with previous results of PMd (Mitz et al, 1991;Brasted and Wise, 2004), the post-IS activity increased most dramatically at the time that the monkey's performance improved most rapidly, the middle phase of learning as defined here.…”

Section: Comparison Of Pmd and Putamen Population Activity Levelssupporting

confidence: 92%

“…Antecedents can include visual and other sensory inputs, and consequents usually involve movements or the targets of movement. Changes in task-related neuronal activity during arbitrary visuomotor learning have been described for dorsal premotor cortex (PMd) (Mitz et al, 1991;Brasted and Wise, 2004), supplementary eye field (Chen and Wise, 1995a, b), frontal eye field (Chen and Wise, 1995b), prefrontal cortex (Asaad et al, 1998;Pasupathy and Miller, 2005), hippocampus (Cahusac et al, 1993;Wirth et al, 2003), striatum Jog et al, 1999;Brasted and Wise, 2004;Pasupathy and Miller, 2005) and globus pallidus (Inase et al, 2001). Neuropsychological studies point to the same neural network (Petrides, 1985;Halsband and Passingham, 1985;Rupniak and Gaffan, 1987;Gaffan and Harrison, 1988;Canavan et al, 1989;Eacott and Gaffan, 1992;Murray and Wise, 1996;Ridley and Baker, 1997;Wang et al, 2000;Bussey et al, 2001Bussey et al, , 2002Brasted et al, 2002Brasted et al, , 2003Barefoot et al, 2002Barefoot et al, , 2003Nixon et al, 2004), as does the neuroimaging literature (Deiber et al, 1991(Deiber et al, , 1997Paus et al, 1993;Toni and Passingham, 1999;Toni et al, 2001Toni et al, , 2002Eliassen et al, 2003).…”

Section: Introductionmentioning

confidence: 95%

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Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings

2005

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A previous study found that as monkeys learned novel mappings between visual cues and responses, neuronal activity patterns evolved at approximately the same time in both the dorsal premotor cortex (PMd) and the putamen. Here we report that, in both regions, the population activity for novel mappings came to resemble that for familiar ones as learning progressed. Both regions showed activity differences on trials with correct responses versus those with incorrect ones. In addition to these common features, we observed two noteworthy differences between PMd and putamen activity during learning. After a response choice had been made, but prior to feedback about the correctness of that choice (reward or nonreward), the putamen showed a sustained activity increase in activity, whereas PMd did not. Also in the putamen, this prereward activity was highly selective for the specific visuomotor mapping that had just been performed, and this selectivity was maintained until the time of the reward. After performance reached an asymptote, the degree of this selectivity decreased markedly to the level typical for familiar visuomotor mappings. These findings support the hypothesis that neurons in the striatum play a pivotal role in associative learning.

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Section: Comparison Of Pmd and Putamen Population Activity Levelssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 95%

Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings

2005

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“…A more ventral and rostral part of the between an imagined trigger stimulus and the motor vPMC is also suggested to be involved in the imagination commands. This interpretation is related to findings linking of complex movements [49], preparation of imitated the caudal part of the dPMC to the learning of visual movements [24], or imitation of movements in general conditional tasks both in monkeys and humans [17,33]. [41, 44,45].…”

Section: Introductionmentioning

confidence: 92%

Cortical activations during paced finger-tapping applying visual and auditory pacing stimuli

Jäncke

Loose

Lutz

et al. 2000

Cognitive Brain Research

271

167

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In order to study neural systems which are involved in motor timing we used whole-brain functional resonance imaging while subjects performed a paced finger-tapping task (PFT) with their right index finger. During one condition, subjects were imaged while tapping in synchrony with tones separated by a constant interval (auditory synchronisation, AS), followed by tapping without the pacing stimulus (auditory continuation, AC). In another condition, subjects were imaged while tapping in synchrony with a visual stimulus presented at the same frequency as the tones (visual synchronisation, VS) followed by a tapping sequence without visual pacing (visual continuation, VC). The following main results were obtained: (1) tapping in the context of visual pacing was generally more variable than tapping in the context of auditory stimuli; (2) during all conditions, a fronto-parietal network was active including the dorsal lateral premotor cortex (dPMC), M1, S1, inferior parietal lobule (LPi), supplementary motor cortex (SMA), the right cerebellar hemisphere, and the paravermial region; (3) stronger activation in the bilateral ventral premotor cortex (vPMC), the left LPi, the SMA, the right inferior cerebellum, and the left thalamus during both auditory conditions (AS and AC) compared to the visual conditions (VS and VC); (4) stronger activation in the right superior cerebellum, the vermis, and the right LPi during the visual conditions (VS and VC); (5) similar activations for the AS and AC conditions; but (6) marked differences between the VS and VC conditions especially in the dorsal premotor cortex (dPMC) and LPi areas; and (7) finally, there were no activations in the auditory and visual cortices when the pacing stimuli were absent. These findings were taken as evidence for a general difference between the motor control modes operative during the auditory and visual conditions. Paced finger tapping in the context of auditory pacing stimuli relies more on brain structures subserving internal motor control while paced finger-tapping in the context of visual pacing stimuli relies on brain structures relying on the subserving processing or imagination of visual pacing stimuli.

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“…The changes in neuronal activity during the whole learning process deserve study. Gradually, learning-related changes in neuronal activity have been shown in several brain areas, such as the PFC [58] , basal ganglia [59] , premotor cortex [60] and supplementary eye field [61] . Experiments in the PFC have shown that learning an arbitrary stimulus-response mapping causes the representation of movement direction to appear earlier in the delay period before the execution of an eye movement.…”

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confidence: 99%

Anticipatory activity in rat medial prefrontal cortex during a working memory task

Bai

Liu

et al. 2012

Neurosci. Bull.

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Objective Working memory is a key cognitive function in which the prefrontal cortex plays a crucial role.This study aimed to show the firing patterns of a neuronal population in the prefrontal cortex of the rat in a working memory task and to explore how a neuronal ensemble encodes a working memory event. Methods Sprague-Dawley rats were trained in a Y-maze until they reached an 80% correct rate in a working memory task. Then a 16-channel microelectrode array was implanted in the prefrontal cortex. After recovery, neuronal population activity was recorded during the task, using the Cerebus data-acquisition system. Spatio-temporal trains of action potentials were obtained from the original neuronal population signals. Results During the Y-maze working memory task, some neurons showed significantly increased firing rates and evident neuronal ensemble activity. Moreover, the anticipatory activity was associated with the delayed alternate choice of the upcoming movement. In correct trials, the averaged pre-event firing rate (10.86 ± 1.82 spikes/ bin) was higher than the post-event rate (8.17 ± 1.15 spikes/bin) (P <0.05). However, in incorrect trials, the rates did not differ. Conclusion The results indicate that the anticipatory activity of a neuronal ensemble in the prefrontal cortex may play a role in encoding working memory events.

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Learning-dependent neuronal activity in the premotor cortex: activity during the acquisition of conditional motor associations

Cited by 339 publications

References 63 publications

Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings

Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings

Cortical activations during paced finger-tapping applying visual and auditory pacing stimuli

Anticipatory activity in rat medial prefrontal cortex during a working memory task

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