Learning from magnetotactic bacteria: A review on the synthesis of biomimetic nanoparticles mediated by magnetosome-associated proteins

Peigneux, Ana; Valverde-Tercedor, Carmen; López-Moreno, Rafael; Pérez-González, Teresa; Fernández-Vivas, M.A.; Jiménez-López, Concepción

doi:10.1016/j.jsb.2016.06.026

Cited by 20 publications

(18 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study of iron biomineralization is a growing interdisciplinary area of modern applied science that involves such fields as biotechnology [ 199 , 200 ], nanotechnology [ 201 , 202 ], biomaterial science, and biomedicine [ 203 , 204 ]. Magnetotactic bacteria and magnetosomes have been recently proposed for application in a variety of fields, including nano-scale engineering [ 205 , 206 ], magnetic hyperthermia, magnetic resonance imaging, nucleotide polymorphism detection, and immunoassays [ 207 , 208 ].…”

Section: Iron Biomineralization and Extremophilic Organismsmentioning

confidence: 99%

Forced Biomineralization: A Review

2021

View full text Add to dashboard Cite

Biologically induced and controlled mineralization of metals promotes the development of protective structures to shield cells from thermal, chemical, and ultraviolet stresses. Metal biomineralization is widely considered to have been relevant for the survival of life in the environmental conditions of ancient terrestrial oceans. Similar behavior is seen among extremophilic biomineralizers today, which have evolved to inhabit a variety of industrial aqueous environments with elevated metal concentrations. As an example of extreme biomineralization, we introduce the category of “forced biomineralization”, which we use to refer to the biologically mediated sequestration of dissolved metals and metalloids into minerals. We discuss forced mineralization as it is known to be carried out by a variety of organisms, including polyextremophiles in a range of psychrophilic, thermophilic, anaerobic, alkaliphilic, acidophilic, and halophilic conditions, as well as in environments with very high or toxic metal ion concentrations. While much additional work lies ahead to characterize the various pathways by which these biominerals form, forced biomineralization has been shown to provide insights for the progression of extreme biomimetics, allowing for promising new forays into creating the next generation of composites using organic-templating approaches under biologically extreme laboratory conditions relevant to a wide range of industrial conditions.

show abstract

Section: Iron Biomineralization and Extremophilic Organismsmentioning

confidence: 99%

Forced Biomineralization: A Review

2021

View full text Add to dashboard Cite

show abstract

“…Learning from nature and understanding how those complex biomineralization processes occur may provide insights for the design of new materials with improved properties. In this context, and taking inspiration from nature, novel magnetosome-like magnetite nanoparticles can be produced by means of magnetosome-associated proteins [2,3]. The main advantage of these magnetosome-like magnetic nanoparticles (namely biomimetic nanoparticles) versus magnetosomes is that their production could be scaled-up easily than that for magnetosomes, and their advantage over inorganic magnetic nanoparticles is that biomimetic ones show novel properties which make them promising nanocarriers [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

et al. 2020

View full text Add to dashboard Cite

Current chemotherapy for colorectal cancer (CRC) includes the use of oxaliplatin (Oxa), a first-line cytotoxic drug which, in combination with irinotecan/5-fluorouracil or biologic agents, increases the survival rate of patients. However, the administration of this drug induces side effects that limit its application in patients, making it necessary to develop new tools for targeted chemotherapy. MamC-mediated biomimetic magnetic nanoparticles coupled with Oxa (Oxa-BMNPs) have been previously demonstrated to efficiently reduce the IC50 compared to that of soluble Oxa. However, their strong interaction with the macrophages revealed toxicity and possibility of aggregation. In this scenario, a further improvement of this nanoassembly was necessary. In the present study, Oxa-BMNPs nanoassemblies were enveloped in phosphatidylcholine unilamellar liposomes (both pegylated and non-pegylated). Our results demonstrate that the addition of both a lipid cover and further pegylation improves the biocompatibility and cellular uptake of the Oxa-BMNPs nanoassemblies without significantly reducing their cytotoxic activity in colon cancer cells. In particular, with the pegylated magnetoliposome nanoformulation (a) hemolysis was reduced from 5% to 2%, being now hematocompatibles, (b) red blood cell agglutination was reduced, (c) toxicity in white blood cells was eliminated. This study represents a truly stepforward in this area as describes the production of one of the very few existing nanoformulations that could be used for a local chemotherapy to treat CRC.

show abstract

“…Magnetite crystals produced using these methods demonstrate that there is little, if any, control over the mineralization process, meaning that the crystals generally do not show a consistent crystal morphology or size. Advances in the characterization of the proteins involved in magnetosome formation in MTB have been applied in the development of biomimetic magnetite nanoparticles [ 34 ]. In these approaches, proteins responsible for the nucleation, pH and redox control in the biomineralization process by MTB are used in in vitro synthesis of magnetite nanoparticles to fine tune desirable crystal features.…”

Section: Resultsmentioning

confidence: 99%

Applications of Magnetotactic Bacteria, Magnetosomes and Magnetosome Crystals in Biotechnology and Nanotechnology: Mini-Review

et al. 2018

View full text Add to dashboard Cite

Magnetotactic bacteria (MTB) biomineralize magnetosomes, which are defined as intracellular nanocrystals of the magnetic minerals magnetite (Fe3O4) or greigite (Fe3S4) enveloped by a phospholipid bilayer membrane. The synthesis of magnetosomes is controlled by a specific set of genes that encode proteins, some of which are exclusively found in the magnetosome membrane in the cell. Over the past several decades, interest in nanoscale technology (nanotechnology) and biotechnology has increased significantly due to the development and establishment of new commercial, medical and scientific processes and applications that utilize nanomaterials, some of which are biologically derived. One excellent example of a biological nanomaterial that is showing great promise for use in a large number of commercial and medical applications are bacterial magnetite magnetosomes. Unlike chemically-synthesized magnetite nanoparticles, magnetosome magnetite crystals are stable single-magnetic domains and are thus permanently magnetic at ambient temperature, are of high chemical purity, and display a narrow size range and consistent crystal morphology. These physical/chemical features are important in their use in biotechnological and other applications. Applications utilizing magnetite-producing MTB, magnetite magnetosomes and/or magnetosome magnetite crystals include and/or involve bioremediation, cell separation, DNA/antigen recovery or detection, drug delivery, enzyme immobilization, magnetic hyperthermia and contrast enhancement of magnetic resonance imaging. Metric analysis using Scopus and Web of Science databases from 2003 to 2018 showed that applied research involving magnetite from MTB in some form has been focused mainly in biomedical applications, particularly in magnetic hyperthermia and drug delivery.

show abstract

Learning from magnetotactic bacteria: A review on the synthesis of biomimetic nanoparticles mediated by magnetosome-associated proteins

Cited by 20 publications

References 81 publications

Forced Biomineralization: A Review

Forced Biomineralization: A Review

Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

Applications of Magnetotactic Bacteria, Magnetosomes and Magnetosome Crystals in Biotechnology and Nanotechnology: Mini-Review

Contact Info

Product

Resources

About