Learning from Nature to Improve the Heat Generation of Iron-Oxide Nanoparticles for Magnetic Hyperthermia Applications

Abstract

The performance of magnetic nanoparticles is intimately entwined with their structure, mean size and magnetic anisotropy. Besides, ensembles offer a unique way of engineering the magnetic response by modifying the strength of the dipolar interactions between particles. Here we report on an experimental and theoretical analysis of magnetic hyperthermia, a rapidly developing technique in medical research and oncology. Experimentally, we demonstrate that single-domain cubic iron oxide particles resembling bacterial magnetosomes have superior magnetic heating efficiency compared to spherical particles of similar sizes. Monte Carlo simulations at the atomic level corroborate the larger anisotropy of the cubic particles in comparison with the spherical ones, thus evidencing the beneficial role of surface anisotropy in the improved heating power. Moreover we establish a quantitative link between the particle assembling, the interactions and the heating properties. This knowledge opens new perspectives for improved hyperthermia, an alternative to conventional cancer therapies.

Synthesis and characterization of superparamagnetic iron-oxide nanoparticles (SPIONs) and utilization of SPIONs in X-ray imaging

“…Magnetization values were found to be below the 0.5 M S for 40 nm cubic particles (MartinezBoubeta et al 2013). In our study, the M S was lesser for our particle, as smaller particles have smaller magnetization (Martinez-Boubeta et al 2013;Disch et al 2012).…”

“…Accordingly, there are different transition fluctuations observed. There was a steady increase in the magnetic moment as the temperature increased up to 200 K and a sudden decrease at 300 K, and again an immediate increase up to 300-350 K, and finally a sudden fall at 400 K. The reduction in coercivity was observed mean particle size that was decreased (Martinez-Boubeta et al 2013). Transition fluctuation in magnetic moment probably due to the different molecular arrangements occurred when the particles were formed in the magnetic field.…”

Enhanced magnetic anisotropy and heating efficiency in multi-functional manganese ferrite/graphene oxide nanostructures

“…Martínez-Boubeta et al 28 have experimentally demonstrated that highly anisotropic long chains of magnetic nanoparticles give rise to the increased SAR. Very recently, we have achieved higher values of the SAR for the cubic FeO/γ-Fe2O3 nanoparticles as compared to their spherical counterpart (200 vs. 135 W/g at 600 Oe) 29 .…”

SiO2 kaplı kübik Fe3O4 nanoparçacıkların sentezlenmesi ve karakterizasyonu

“…Kübik Fe 3 O 4 nanoparçacıkların kimyasal yöntem kullanılarak sentezlenmesi Bu sentez işleminde Martinez-Baubeta ve arkadaşlarının 2013 yılında yaptıkları çalışma temel alınmıştır [11]. Örneklerin hazırlanmasında izole edilmiş Schlenk sisteminden, 15 dakika süre ile azot gazı geçirilerek içeride bulunan oksijen gazı dışarıya atıldı.…”