Objective. To design and evaluate the use of simulations to prepare students to identify and reduce medication errors and promote patient safety.Methods. Third year pharmacy students used methods of root cause analysis to determine the cause of a medication error in three simulated pharmacy settings. Prior to and following the activity, students were invited to complete an anonymous survey. Students were asked to complete a modified Healthcare Professionals Patient Safety Assessment instrument to measure changes in knowledge, skills, and attitudes.Results. Ninety out of 165 students submitted complete data sets for analysis. Students demonstrated significant changes in knowledge, skills, and attitudes regarding medication errors. They felt they could find the cause of an error, identify factors leading to an error, and work with a team to prevent error recurrence. Students also demonstrated an increase in knowledge about medication related errors and the root cause analysis process.