Learning large‐scale spatial relationships in a maze and effects of MK‐801 on retrieval in the rhesus monkey

Wang, Jian Hong; Zhang, Bo; Meng, Zhibin; Sun, Ning; Xiu, Man; Zhang, Hua Xian; Tang, Xiangdong; Sanford, Larry D.; Wilson, Fraser A.W.; Hu, Xin; Carlson, Synnöve; Ma, Yuanye

doi:10.1002/dneu.20547

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…These observations, together with the present data, suggest that a component of this cognitive impairment could be associated with their non-competitive inhibition of NNRs. For example, it is well established that chemical blockade with compounds such as mecamylamine (Newhouse et al, 1994) or MK-801 (Wang et al, 2007) or biological interference using animal knock-out models of either α4β2 (Hogg et al, 2003) or α7 NNRs (Young et al, 2007) can produce cognitive dysfunction. However the fact that the atypical antipsychotics are generally less likely to induce cognitive impairment suggests a more complicated relationship.…”

Section: Discussionmentioning

confidence: 99%

Atypical antipsychotics as noncompetitive inhibitors of α4β2 and α7 neuronal nicotinic receptors

Grinevich¹,

Papke

Lippiello³

et al. 2009

Neuropharmacology

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It has been suggested that the interaction of antipsychotic medications with neuronal nicotinic receptors may increase the cognitive dysfunction associated with schizophrenia and may explain why current therapies only partially address this core feature of the illness. In the present studies we compared the effects of the atypical antipsychotics quetiapine, clozapine and N-desmethylclozapine to those of the typical antipsychotics haloperidol and chlorpromazine on the α4β2 and α7 nicotinic receptor subtypes. The binding of [3H]-nicotine to rat cortical α4β2 receptors and [3H]-methyllycaconitine to rat hippocampal α7 receptors was not affected by any of the compounds tested. However, Rb+ efflux evoked either by nicotine or the selective α4β2 agonist TC-1827 from α4β2 receptors expressed in SH-EP1 cells and nicotine-evoked [3H]-dopamine release from rat striatal synaptosomes were non-competitively inhibited by all of the antipsychotics. Similarly, α-bungarotoxin-sensitive epibatidine-evoked [3H]-norepinephrine release from rat hippocampal slices and acetylcholine-activated currents of α7 nicotinic receptors expressed in oocytes were inhibited by haloperidol, chlorpromazine, clozapine and N-desmethylclozapine. The inhibitory effects on nicotinic receptor function produced by the antipsychotics tested occurred at concentrations similar to plasma levels achieved in schizophrenia patients, suggesting that they may lead to clinically relevant effects on cognition.

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Section: Discussionmentioning

confidence: 99%

Atypical antipsychotics as noncompetitive inhibitors of α4β2 and α7 neuronal nicotinic receptors

Grinevich¹,

Papke

Lippiello³

et al. 2009

Neuropharmacology

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“…For non-human primates, tasks that involve responding to computer screens require extensive training. In contrast, spatial information is acquired quickly in three-dimensional environments (Wang et al, 2007; Zhang et al, 2008; Haley et al, 2009). A number of spatial mazes have been developed to examine the rate of learning and duration of retention for hippocampal-dependent spatial working and reference memory in rodents, including stone maze, radial maze, Morris water maze, Barnes maze, and T-maze (Barnes, 1979; Morris et al, 1982; Beatty et al, 1985; Ingram, 1988; Bimonte et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Characterizing cognitive aging of spatial and contextual memory in animal models

Foster¹,

DeFazio²,

Bizon³

2012

Front. Ag. Neurosci.

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Episodic memory, especially memory for contextual or spatial information, is particularly vulnerable to age-related decline in humans and animal models of aging. The continuing improvement of virtual environment technology for testing humans signifies that widely used procedures employed in the animal literature for examining spatial memory could be developed for examining age-related cognitive decline in humans. The current review examines cross species considerations for implementing these tasks and translating findings across different levels of analysis. The specificity of brain systems as well as gaps in linking human and animal laboratory models is discussed.

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“…While a few other laboratories have developed spatial tests with allocentric representation for nonhuman primates (Rapp et al, 1997; Hampton et al, 2004; Wang et al, 2007; Ludvig et al, 2003), their tests are different from the test used in this study. One major difference is in some of the former tests (Rapp et al, 1997; Hampton et al, 2004) the animals were tethered and this restraint could have interfered with their behavior.…”

Section: Discussionmentioning

confidence: 99%

“…A few other investigators have developed spatial tasks requiring navigation for nonhuman primates (Rapp et al, 1997; Hampton et al, 2004; Zhang et al, 2008; Wang et al, 2007), including one for squirrel monkeys using eight food ports, four of them baited with a preferred food reward each trial (Ludvig et al, 2003). In the current study we evaluated the performance of aged rhesus monkeys in a task where only one out of ten ports was baited.…”

Section: Introductionmentioning

confidence: 99%

Circadian activity associated with spatial learning and memory in aging rhesus monkeys

Haley

Landauer

Renner

et al. 2009

Experimental Neurology

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In rodents, spatial learning and memory tests require navigation, whereas in nonhuman primates these tests generally do not involve a navigational component, thus assessing nonhomologous neural systems. To allow closer parallels between rodent and primate studies, we developed a navigational spatial learning and memory task for nonhuman primates and assessed the performance of elderly (19-25 years) female rhesus monkeys (Macaca mulatta). The animals were allowed to navigate in a room containing a series of food ports. After they learned to retrieve food from the ports, a single port was repeatedly baited and the animals were tested until they learned the correct location. The location of the baited port was then changed (shift position). We also determined whether test performance was associated with circadian activity measured with accelerometers. Performance measures included trials to criterion, search strategies, and several indices of circadian activity. Animals learned the task as reflected in their search strategies. Correlations were found between the number of initial or shift trials and circadian activity parameters including day activity, dark:light activity ratio, sleep latency, and wake bouts. Thus, disruptions in circadian rhythms in nonhuman primates are associated with poorer performance on this novel test. These data support the usefulness of this spatial navigational test to assess spatial learning and memory in rhesus monkeys and the importance of circadian activity in performance.

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Learning large‐scale spatial relationships in a maze and effects of MK‐801 on retrieval in the rhesus monkey

Cited by 10 publications

References 32 publications

Atypical antipsychotics as noncompetitive inhibitors of α4β2 and α7 neuronal nicotinic receptors

Atypical antipsychotics as noncompetitive inhibitors of α4β2 and α7 neuronal nicotinic receptors

Characterizing cognitive aging of spatial and contextual memory in animal models

Circadian activity associated with spatial learning and memory in aging rhesus monkeys

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