Digital-based education is an educational innovation that is integrated with information and communication technology. In welcoming education 4.0, digital-based education has previously been developed such as the use of digital devices and start-ups or learning applications that are tailored to the needs of students. Since the COVID-19 pandemic broke out, the digitalization of education has grown and is indispensable in the practice of distance learning. Learning that previously took place face-to-face was forced to switch to online learning, thus demanding the digitization of media, materials, and learning activities. In the post-pandemic era, digital-based education must continue to be developed to build better education. This article aims to explain the opportunities, challenges, and practices of digital-based education based on a study of several scientific journals. The research method used in this article is a literature study from several international journal databases. The results of this literature study can be used as consideration for educators, government, and learning technology developers so that the implementation of education is more relevant and effective in improving the quality of human resources.