Background: During the COVID-19 era, the educational system was modified to include blended learning, using a multi-delivery mode to optimize outcome and have the best program delivery cost. Identifying students' learning styles (LS) is an important factor that contributes to scholastic accomplishment, resulting in a more satisfying learning. Objectives: To describe the learning style preferences among medical students at Ain Shams University; to investigate the associations between LS and academic achievement; and lastly, to determine whether preclinical and clinical students differ in their LS. Method: A cross-sectional study was conducted among a sample of 262 students using a self-administered questionnaire including socio-demographic data, academic achievement, and the Barsch Learning Styles Inventory. Results: The unimodal pattern of learning was the most prevalent style among surveyed students; about half of them used the unimodal visual style (49.6%) while the trimodal style was the least (0.8%). The most reported preferred educational materials include the private lessons summary (64.8%) and the faculty books (61.4%). The most frequently reported educational source was recorded audios (82.4%). The LS preference did not differ between preclinical and clinical students. Conclusion and recommendations: The unimodal visual style was the predominant among surveyed students. Age, gender, academic year, study hours, and LS explain 59% of the variation in academic performance. Education and training in medicine need innovative ideas that match the students' styles. Educators should create a conducive atmosphere for learning and use methods of delivery that appeal to the senses using visual aids and materials to accommodate different learners.