Many scholars have conducted extensive research on the adoption behavior of mobile readers, and there are obvious differences in the degree and direction of conclusions drawn from different individual studies. In this study, a meta-analysis method was used to comprehensively analyze a total of 74,964 independent samples of 31 relevant empirical research documents at home and abroad. The results show that the main influencing factors of mobile reading are perceived usefulness, perceived ease of use, perceived mobility, perceived entertainment, social influence, cognitive adjustment, perceived value, usage attitude, interface design, etc. Cognitive adjustment and usage attitude have the greatest impact on intention to use, followed by perceived usefulness, perceived mobility, subjective norms, perceived ease of use; perceived ease of use has a significant positive impact on perceived usefulness; interface design has a significant positive effect on perceived ease of use; behavioral intention has a significant positive effect on actual behavior; and perceived usefulness and perceived ease of use have a significant positive effect on usage attitude.