In this study, we exploratively investigate the relation between students’ epistemological beliefs and their declarative knowledge about scientific explanations and their practical skills to explain psychological phenomena drawing on scientific theories before and after a training intervention using a person-centered approach. We theoretically derive profiles of epistemological beliefs that should be beneficial for constructing scientific explanations. Using a latent profile transition analysis and a sample with N=108 students, we explore which profiles of epistemological beliefs, declarative knowledge about explanations, and explanation skills empirically emerge before and after an intervention that aimed and fostering students’ skills to construct scientific explanations. Before the intervention, two profiles emerged that differed in epistemological beliefs and explanation skills, but both did not in declarative knowledge about explanation. Consistent with theoretical expectations, those having higher explanation skills have more beneficial epistemological beliefs. The intervention, in general, yielded a gain in declarative knowledge about explanations and explanation skills. After the intervention, again, two profiles emerged. However, these profiles did not differ in their epistemological beliefs but only in declarative knowledge about explanations and explanation skills. Thus, the intervention seems to level out the effects of epistemological beliefs. Additionally, the pattern of change in epistemological beliefs is consistent with theoretical expectations about which epistemological beliefs are beneficial for explanations. We discuss the results and their implications, as well as their limitations. Finally, we provide an outlook of using the person-oriented approach and this study’s type of intervention in the research on changing epistemological beliefs.