In the conditions of the fourth industrial revolution and the new digital era, modern corporations in their development are focusing more and more on the wide and optimal use of digital technologies in various fields of their activity. In this regard, it becomes very important for the universities to start preparing future graduates for work with digital technologies in a timely manner so that they are in demand and competitive in the labor market in the future. Objectives of the study. The article reveals the current state, directions of digital transformation and the ways of transition of universities to 4.0 model. Achieved results. We have revealed the peculiarities of digitalization of the main types of university activities in the new conditions during the transition to 4.0 model. We have formulated the changes in the educational, research and business activities of the university in the digital economy.