Lebensbedrohliche Komplikationen von Morbus Crohn und Colitis ulcerosa

Huber, W.; Herrmann, G.; Schuster, T; Phillip, Veit; Saugel, Bernd; Schultheiß, Caroline; Hoellthaler, J; J, Gaa; Hartel, Mark; Schmid, R; Reindl, Wolfgang

doi:10.1055/s-0030-1251915

Cited by 11 publications

(10 citation statements)

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“…9 Huber et al reported on 28 patients admitted to a German university hospital ICU between 1991 and 2008 and found a case-fatality rate of 18%, of which all deaths were all attributed to infectious complications. 10 This study was published in German and only the English language abstract was reviewed. Most…”

Section: Discussionmentioning

confidence: 99%

“…The cohort of patients we describe in this study represents approximately one-fourth of the overall total reported in the literature we identified. 9,10,12 Additionally, similar to the studies from Manitoba, we used a population-based design that minimises selection bias and allows reporting of incidence and mortality rates. 23 This is an important consideration, as while single hospital-based studies may inform clinical experience, they are at particular risk for referral bias.…”

Section: Discussionmentioning

confidence: 99%

“…There is a paucity of previously published works to compare our results. We conducted ad hoc PubMed searches and scanned bibliographies of identified articles but were only able to identify three previous studies conducted in ICU that focussed on IBD 9,10,12 . Ha et al .…”

Section: Discussionmentioning

confidence: 99%

“…Our study is an important addition to the small body of previously published literature investigating the occurrence and determinants of ICU admissions among patients with IBD. The cohort of patients we describe in this study represents approximately one‐fourth of the overall total reported in the literature we identified 9,10,12 . Additionally, similar to the studies from Manitoba, we used a population‐based design that minimises selection bias and allows reporting of incidence and mortality rates 23 .…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11][12][13] studies have reported that IBD patients represent approximately 1% of admissions to ICU and suffer an associated 30-day case fatality of up to 20%. [9][10][11] However, studies conducted in selected cohorts are at high risk for selection biases. 14 To our knowledge, population-based data surrounding the epidemiology of ICU admission among patients with IBD has only been reported from Manitoba, Canada.…”

Section: Introductionmentioning

confidence: 99%

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Excess burden of critical illness related to inflammatory bowel disease

Laupland

Shekar

Tabah

et al. 2022

Internal Medicine Journal

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Background Although inflammatory bowel disease (IBD) is associated with major morbidity and mortality, few studies have evaluated its associated burden of critical illness. Aims To examine the epidemiology and outcome of intensive care unit (ICU) admission among patients with IBD in North Brisbane, Australia. Methods A population‐based cohort design was used. All admissions to ICU serving the Metro North Hospital and Health Service among adult residents during 2017–2019 were included. Data were obtained from ICU clinical information systems with linkages to statewide admissions and death registries. Results Among 9011 ICU admissions, 101 (1.1%) were among patients with IBD, of which 57 (0.6%) and 44 (0.5%) had ulcerative colitis (UC) and Crohn disease (CD) respectively. The incidence of ICU admission was 379, 1336, 1514 and 1429 per 100 000 annually among those without IBD, CD, UC and IBD respectively. Patients with IBD were at excess risk for admission across all age groups, with women aged <50 years at highest risk and men thereafter. The all‐cause 90‐day case‐fatality rates following ICU admission were not significantly different among patient groups and were 18%, 12%, 15% and 12% for CD, UC, IBD and non‐IBD respectively. However, as compared with non‐IBD patients, those with CD (151.8 vs 39.4 per 100 000; relative risk (RR) 3.85; 95% confidence interval (CI) 1.25–9.02; P = 0.013), UC (159.4 vs 39.4 per 100 000; RR 4.05; 95% CI 1.48–8.84; P = 0.005) and IBD (155.6 vs 39.4 per 100 000; RR 3.95; 95% CI 1.96–7.10; P = 0.002) were at significantly higher risk for mortality. Conclusions Patients with IBD suffer a major burden of critical illness.

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Section: Discussionmentioning

confidence: 99%