Lebensdauer und Abbauort menschlicher Thrombozyten bei unterschiedlichen Thrombopenieformen

Gehrmann, G; Bleifeld, W.

doi:10.1007/bf01631945

Cited by 13 publications

(4 citation statements)

References 7 publications

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“…Aster & Jandl (1964) studied one patient and foutid that corticosteroids not only prolonged platelet survival, but also increased platelet production about two times. Gehrmann & Bleifeld (1968) observed in one patient an even higher in-crease in platelet production. On the other hand Najean et al (1963) found a normal platelet production during treatment with corticosteroids.…”

mentioning

confidence: 83%

Platelet Survival and Platelet Production in Idiopathic Thrombocytopenic Purpura (ITP) before and during Treatment with Corticosteroids

Branehög

Weinfeld

1974

Scandinavian Journal of Haematology

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Platelet mean life span (MLS) and platelet production were studied in 11 patients with idiopathic thrombocytopenic purpura (ITP) before and after institution of corticosteroids. Platelet MLS was greatly reduced before treatment. A prolongation of MLS was observed in every patient during corticosteroid therapy but there was in no case a normalization of platelet MLS. Platelet production was significantly above normal in untreated ITP and did not change significantly during corticosteroid treatment. The partial compensation of the platelet count during treatment was due to an increase of platelet MLS and a continued unchanged elevated platelet production. Recovery of infused labelled platelets was greatly reduced in ITP and was closely related to platelet MLS. During corticosteroid treatment the recovery values increased significantly. The survival curve in ITP consists of a rapid component terminated 15 min after infusion and a second one with a slower disappearance rate. The percentage platelet recovery is dependent on the magnitude of the first component. Due to limitations of splenic blood flow the rapid initial platelet destruction is mainly accomplished by the liver. In untreated ITP with a high rate of initial platelet destruction a greater amount of radioactivity would accumulate in this organ. Accordingly external surface counting of radioactivity has shown an increase in the spleen to liver ratio during corticosteroid treatment.

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mentioning

confidence: 83%

Platelet Survival and Platelet Production in Idiopathic Thrombocytopenic Purpura (ITP) before and during Treatment with Corticosteroids

Branehög

Weinfeld

1974

Scandinavian Journal of Haematology

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“…This was explained by the fact that the biologic half-life of the 14C tag was longer in membranes than in all other components, and that the fast initial disappearance rate was missing in membranes. The half-life of activity in mem branes was corresponding to the figures given for the half-life of normal platelets in circulation (8,10). This means that an irreversible acetylation of the platelet membranes occurred and that a diminution of activity in platelet membranes was only achieved by a simultaneous diminution of the platelet population and by the appearance of new platelets which had not been in touch with ASA.…”

Section: Discussionmentioning

confidence: 99%

Uptake by Blood Components and by Subcellular Platelet Fractions of 1-<sup>14</sup>C-Acetylsalicylic Acid

Vinazzer¹,

Zolle²,

Loew³

1978

Pathophysiol Haemos Thromb

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1-¹⁴C-Acetylsalicylic acid was used to study the distribution and the kinetics of the acetyl group in blood components. Tests were carried out in 4 patients in vivo and on four blood samples in vitro. At various intervals after tagging, whole blood, plasma, platelets and platelet fractions were examined. In vitro, relative activity was found to be higher in platelets than in all other blood components. When platelet fractions were examined, the highest specific activity was found in membranes. In vivo, rapid disappearance of activity from circulation was observed. The decrease of activity was slower in platelets than in whole blood and in plasma. The highest specific activity was again found in platelet membranes. The half-life of the ¹⁴C tag was measured in all components. It was found to be longest in platelet membranes where it corresponded to the half-life of platelets in circulation. From the results obtained, the conclusion was drawn that irreversible acetylation of the platelet membrane must be considered to be one of the main causes of platelet dysfunction induced by acetylsalicylic acid.

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“…Obwohl die Bestimmung der Thrombozytenlebensdauer erst fünf Tage nach Klinikaufnahme erfolgen konnte, war sie mit einem Wert von 24 Stunden erheblich verkürzt bei einem erniedrigten Recoverywert von 240/o (Normalwerte 8 bis 11 Tage bei einem Recoverywert von rund 6O°/o [6]). Der Abbau der Thrombozyten erfolgte lienal-hepatogen.…”

Section: Beim Erwachsenenunclassified

“…96 ( ), 1494 vorliegen oder nicht. Wenn auch die Erkrankung im allgemeinen einen spontanen Heilverlauf nimmt, sind Nebennierenrindenhormone zumindest bei ausgeprägten Thrombozytopenien angezeigt, denn durch sie kann nicht nur der beschleunigte Thrombozytenabbau hintangehalten, sondern auch die Thrombozytenproduktion gesteigert werden (6). Thrombozytenkonzentrat-Infusionen sind, wie auch unser Fall 3 belegt, entsprechend den pathogenetischen Vorstellungen nur von sehr begrenzter Wirkung.…”

Section: Diskussionunclassified

Akuter postinfektiöser Morbus Werlhof beim Erwachsenen

Selgrad¹,

Elbers²,

Gehrmann³

1971

Dtsch med Wochenschr

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Das bereits 1735 von Werlhof beschriebene Krankheitsbild des »Morbus maculosus haemorrhagicus« hat erst in den letzten 15 Jahren durch klinische Beobachtungen, immunologische Befunde und nicht zuletzt durch die Möglichkeit, die Thrombozytenlebensdauer zu bestim-* Addendum: Inzwischen haben wir einen weiteren Fall von postinfektiösem Morbus Werihof bei einer 6ojährigen Patientin beobachtet, der deshalb von besonderer Bedeutung ist, weil im Anschluß an die spontane Heilung eine Normalisierung der ursprünglich mit 2 Stunden exzessiv verkürzten Thrombozytenlebensdauer gesichert werden konnte. Unseres Wissens handelt es sich dabei um die erste diesbezügliche Befunderhebung bei einem akuten Morbus Werihof.

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Lebensdauer und Abbauort menschlicher Thrombozyten bei unterschiedlichen Thrombopenieformen

Cited by 13 publications

References 7 publications

Platelet Survival and Platelet Production in Idiopathic Thrombocytopenic Purpura (ITP) before and during Treatment with Corticosteroids

Platelet Survival and Platelet Production in Idiopathic Thrombocytopenic Purpura (ITP) before and during Treatment with Corticosteroids

Uptake by Blood Components and by Subcellular Platelet Fractions of 1-<sup>14</sup>C-Acetylsalicylic Acid

Akuter postinfektiöser Morbus Werlhof beim Erwachsenen

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