Lecithin: Cholesterol acyltransferase and lysolecithin in coronary atherosclerosis

Effects of Serum Amyloid A and Lysophosphatidylcholine on Intracellular Calcium Concentration in Human Coronary Artery Smooth Muscle Cells

“…65) In addition, atherosclerotic arteries have been reported to be chronically exposed to high concentrations of LPC as compared with normal arteries. 17,18) Wells, et al (1986) 16) reported that the changes in LPC concentrations from 87 to 292 µM tend to parallel the plasma activity levels of LCAT, which are increased when the severity of coronary atherosclerosis increases. Thus, LPC may accumulate in pathophysiological conditions such as ischemia and atherosclerosis.…”

“…[13][14][15] LCAT activity levels have also been reported to be increased depending on the severity of coronary atherosclerosis and the changes in the activity of this enzyme are appropriately reflected by an increase in LPC concentration in plasma. 16) Thus, atherosclerotic arteries are chronically exposed to high concentrations of LPC as compared with normal arteries. 17,18) LPC-mediated biological effects are diverse on numerous types of cells, including coronary artery cells.…”

Role of LCAT in Atherosclerosis

“…Few years later, LCAT activity was found to be positively associated with the severity of coronary atherosclerosis in patients with coronary atherosclerosis 40) . A similar study conducted in 1994 showed contradictory results.…”

Differential lipid metabolism in monocytes and macrophages: influence of cholesterol loading

“…In addition to cholesterol, plasma components such as lysophosphatidylcholine (lyso-PC), which is increased in dyslipidemic serum (18)(19)(20), and which has a great affi nity for cholesterol ( 21 ), might have a role in the cholesterol enrichment of monocytes. More importantly, lyso-PC levels are increased during the oxidation of LDL ( 22 ).…”