1979
DOI: 10.1042/cs0560575
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Lecithin—Cholesterol Acyltransferase and the Lipoprotein Abnormalities of Parenchymal Liver Disease

Abstract: 1. Detailed studies have been made of the plasma lipoprotein abnormalities in parenchymal liver disease to test the hypothesis that the abnormalities would correlate with plasma lecithin-cholesterol acyltransferase (LCAT) activity. 2. When LCAT was high, very-low-density-lipoproteins (VLDL) were normal in composition and had a normal pre-beta electrophoretic mobility. When LCAT was low, VLDL concentrations were greatly reduced. 3. With high LCAT low-density lipoproteins (LDL) were normal. The LDL particles fou… Show more

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Cited by 36 publications
(18 citation statements)
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“…As also demonstrated by others (5,13,14), plasma lipoprotein levels were lower in patients with liver failure than in the normal subjects. Apolipoproteins A and B were also about 26% lower in the LF group compared to the control group.…”
Section: Discussionsupporting
confidence: 52%
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“…As also demonstrated by others (5,13,14), plasma lipoprotein levels were lower in patients with liver failure than in the normal subjects. Apolipoproteins A and B were also about 26% lower in the LF group compared to the control group.…”
Section: Discussionsupporting
confidence: 52%
“…We deliberately chose patients with bilirubin levels lower than 3.0 mg/dl to exclude patients with hyperbilirubinemia which interferes with colorimetric assays of plasma lipids. We also excluded patients with biliary cholestasis because of the known presence of large particles rich in free cholesterol and phospholipids in these patients that resemble LDL, the lipoprotein X (5,12).…”
Section: Discussionmentioning
confidence: 99%
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