Lecithin-linker formulations for self-emulsifying delivery of nutraceuticals

Chu, Jacquelene; Cheng, Yu-Ling; Rao, A. Venketeshwer; Nouraei, Mehdi; Zarate-Muñoz, Silvia; Acosta, Edgar

doi:10.1016/j.ijpharm.2014.05.001

Cited by 15 publications

(7 citation statements)

References 53 publications

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“…EOs nanoemulsions have been stabilized by using nonionic ethoxylated sorbitan esters surfactants to attain oil-in-water (O/W) emulsions (Prakash et al, 2018). The presence of the surfactant or linker molecule allows a gradual polarity change at the vicinity of the interface (shell of the capsule), and thus more beneficial interactions between surfactant-aqueous phase and surfactantoil phase where solubilized EOs bioactive compounds are encountered (Chu et al, 2014;Salager et al, 2005Salager et al, , 2019. This allows the Winsor R relation (Bourrel & Schechter, 2010;Salager al., 2022;Winsor, 1954) to become R < 1 (i.e., hydrophiliclipophilic deviation, HLD N < 0) if an O/W emulsion is the target (Forgiarini et al, 2021;Salager et al, 2020).…”

Section: Encapsulation Of Eosmentioning

confidence: 99%

Nanoparticles and essential oils with antiviral activity on packaging and surfaces: An overview of their selection and application

Márquez

Zwilling

Zambrano

et al. 2022

J Surfact & Detergents

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Until recently, food packaging has been used as a barrier to unfavorable environmental and microbial conditions, but new technologies are arising aimed at upgrading the protective nature of these materials. Cases of bacterial and viral transmission through food and surfaces have shown the vulnerabilities of the food packaging distribution systems over the years, creating awareness about new methods to prevent the proliferation of pathogens. This has been highlighted by safety concerns due to the COVID‐19 pandemic. This work reviews the state‐of‐the‐art biobased technologies tailored for antiviral applications on surfaces, focusing on packaging materials. A survey and selection tool of essential oils (EOs) and nanoparticles that have been proven effective in reducing the proliferation or transmission of viruses through surfaces is presented. Additionally, the use of essential oil formulations or nanoparticle‐functionalized biobased materials that can be deployed to prevent virus transmission through food produce and surfaces is reviewed, including environmental and safety concerns around the use of metal nanoparticles and EOs in packaging materials. Finally, an assessment of the available technologies, challenges, opportunities and the potential role of biobased antiviral surfaces in future viral outbreaks is presented.

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Section: Encapsulation Of Eosmentioning

confidence: 99%

Nanoparticles and essential oils with antiviral activity on packaging and surfaces: An overview of their selection and application

Márquez

Zwilling

Zambrano

et al. 2022

J Surfact & Detergents

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“…The principles of zipper-like assembly were proposed by Acosta et al, 22 and the first time the term was used was in the work of Chu et al 23 The zipper-like assembly is based on the observation that a pair of highly lipophilic and highly hydrophilic amphiphiles (linkers) did not produce a middlephase microemulsion (μE) or ultralow IFT when they were combined. Instead, the lipophilic amphiphile remained in the oil phase and the hydrophilic amphiphile remained in the aqueous phase.…”

Section: Introductionmentioning

confidence: 99%

“…The partition of NA, and possibly NaN, into the oil and aqueous phases is a potential explanation for failure in producing middle-phase microemulsions and ultralow IFTs in partially neutralized NA systems. The zipper-like assembly used with linker (surfactant-like) molecules, , via the introduction of a balanced surfactant, could mitigate surfactant partitioning and manifest the expected ultralow IFTs.…”

Section: Introductionmentioning

confidence: 99%

Zipper-Like Linker Self-Assembly to Obtain Low Interfacial Tensions with Partially Neutralized Naphthenic Acids

Perez-Franco,

Acosta

2024

Energy Fuels

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The presence of naphthenic acid in crude oil is considered one of the most important factors in the formation and stabilization of water in bitumen emulsions. While naphthenic acids (NAs) are oil-soluble lipophilic amphiphiles, their neutralized form, sodium naphthenate (NaN), has highly hydrophilic components. The right NA/NaN proportion should produce a balanced, net-zero curvature at the oil−water interface, leading to ultralow interfacial tensions (IFTs < 0.1 mN/m). A previous study showed that such an expectation is not achievable in model oil systems with NA and NaN, likely because of the partition of NA and NaN species. This work explores the hypothesis that it is possible to achieve ultralow IFTs using surfactants with balanced hydrophilic−lipophilic interactions that can trigger a "zipper-like" self-assembly of hydrophilic and lipophilic amphiphiles at the interface. A second hypothesis is that by producing these ultralow IFTs, one can achieve fast dewatering of emulsions of oil containing partially neutralized NAs. After introducing sodium dihexyl sulfosuccinate (SDHS) and sodium dioctyl sulfosuccinate (Aerosol OT or AOT) as balanced surfactants, it was noted that one could produce ultralow IFTs in partially neutralized NAs. Using the hydrophilic−lipophilic difference (HLD) and net-average curvature (NAC) framework, it was possible to reproduce the experimental trends when using appropriate values for the critical micelle concentration (CMC) for NaN and SDHS. The best zipper-assembly performance was obtained when the intrinsic HLD of the balanced surfactant is near zero. Under those conditions, it was possible to find ultralow IFTs and fast dewatering of emulsions with NA content and pH relevant to diluted bitumen emulsions obtained during naphthenic froth treatment.

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“…Commercial surfactants are found in skin/hair care products and drug delivery systems, which are used in environmental remediation, food processing, and protein extraction because of their low interfacial area, toxicity, and electrolyte resistance . Because of the effectiveness of the surfactants in hard water, it plays a wider role in industrial innovation and maintains its safety in the acidic, neutral, and basic media, which show the compatibility of the skin properly and can be formulated using ionic surfactants . The surface molecules have a high efficiency that makes them sustainable manufactured sources and are more effective in their applications to create new materials .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Pyrimidine and Pyran Derivatives with the Related Systems and the Study of Their Behavior in the Liquid Solutions

El‐Sayed

Katouah

2019

Journal of Heterocyclic Chem

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This study aims to synthesis of condensed and non‐condensed heterocyclic rings with long fatty chains as surface active biological compounds. 2‐Cyano‐3‐(dimethylamino)‐N‐octadecylacrylamide (5) was used to synthesize pyrimidine, pyran, and other condensed products by interacting with appropriate chemical reagents. These compounds were transferred to nonionic surface‐active agents by condensation with propylene oxide. The surface and biological properties showed that these compounds have a high solubility that helps them in easy absorption and adsorption with other compounds. In addition, they have a high ability to decrease the surface tension of the liquids, good wetting, and emulsification power, which can be used at different temperatures without losing their surface or biological properties and enable them for use in industrial and pharmaceutical purposes easily.

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Lecithin-linker formulations for self-emulsifying delivery of nutraceuticals

Cited by 15 publications

References 53 publications

Nanoparticles and essential oils with antiviral activity on packaging and surfaces: An overview of their selection and application

Nanoparticles and essential oils with antiviral activity on packaging and surfaces: An overview of their selection and application

Zipper-Like Linker Self-Assembly to Obtain Low Interfacial Tensions with Partially Neutralized Naphthenic Acids

Synthesis of Pyrimidine and Pyran Derivatives with the Related Systems and the Study of Their Behavior in the Liquid Solutions

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