Lecithin Organogels in Enhancing Skin Delivery of Drugs

Shaikh, I. M.; Jadhav, Kisan R.; Kadam, Vilasrao J.

doi:10.1007/978-3-662-45013-0_21

Cited by 3 publications

References 52 publications

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Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Sagiri

Kasiviswanathan

Shaw

et al. 2016

Korean J. Chem. Eng.

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The current study describes the effect of the concentration of Span 60 (gelator) on the properties of oleogels. Mustard oil was chosen as the representative vegetable oil. Microscopy showed that an increase in the gelator concentration resulted in the increase in the gelator network density. Thermal studies (crystallization kinetics and differential scanning calorimetry) indicated a 2-stage crystallization process. An increase in the gelator proportion resulted in the increase in the compatibility amongst the oleogel components. The formation of gelator network was governed by the interaction amongst the hydroxyl groups of Span 60. A variation in the gelator proportion resulted in the alteration in the d-spacing, crystallite size and lattice strain. The variation in the above-mentioned properties was found to affect the viscoelastic properties of the oleogels as was predicted from the Weichert model. The drug release studies suggested that the drug diffusion due to the gelator network relaxation during drug release was predominant as compared to the Fickian diffusion. The results suggested that it is possible to alter not only the release profile of drugs but also the physical properties (of the oleogels) by tailoring the gelator concentration.

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Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Sagiri

Kasiviswanathan

Shaw

et al. 2016

Korean J. Chem. Eng.

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Nanotechnology for Psoriasis Therapy

2019

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Organogel: A Propitious Carman in Drug Delivery System

Bedse¹,

Singh²,

Raut³

et al. 2023

Advanced Drug Delivery Systems

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A gel is a semi-solid formulation having an external solvent phase that is either apolar (organogels) or polar (hydrogels) that is immobilized inside the voids contained in a three-dimensional networked structure. Organogels are bi-continuous systems composed of apolar solvents and gelators. When used at a concentration of around 15%, the gelators form self-assembled fibrous structures that become entangled with one another, resulting in the formation of a three-dimensional networked structure. The resulting three-dimensional networked structure blocks the flow of the external apolar phase. Sterol, sorbitan monostearate, lecithin, and cholesteryl anthraquinone derivatives are examples of gelators. The unique characteristics such as thermo-reversibility, viscoelasticity, and versatility impart a longer shelf-life, prolonged drug release, and patient compliance. These characteristics can easily be adjusted by simple formulation modifications, resulting in highly-structured architectures. Organogels are more likely to be used in various types of delivery systems because of their ability to entrap both hydrophilic and hydrophobic molecules inside their structure. Their combination with other materials allows for tailoring their potential as dosage forms. Organogels have potential applicability in numerous ways; hence this article discusses the various aspects of it.

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Lecithin Organogels in Enhancing Skin Delivery of Drugs

Cited by 3 publications

References 52 publications

Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Nanotechnology for Psoriasis Therapy

Organogel: A Propitious Carman in Drug Delivery System

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