LecithiniCholesterol Acyltransferase Activity and HDL Composition in Serum of Patients with Kidney Transplants

Abstract

In comparison with a control group, lecithinxholesterol acyltransferase activities and HDL-cholesterol concentrations in serum of patients with kidney transplants were unchanged, while apolipoprotein A and HDL-triglyceride concentrations were increased. This constellation shows that the cholesterol metabolism in patients with kidney transplants differs from that of patients undergoing chronic haemodialysis.

Comparison of Several Atherogenicity Indices by the Analysis of Serum Lipoprotein Composition in Patients with Chronic Renal Failure with or without Haemodialysis, and in Renal Transplant Patients

“…This phenomenon could be independent of the HDL enrichment with triglycerides äs suggested by Rapoport et al (18) and could be a primary phenomenon. For renal transplant patients the HDL-cholesterol/ apolipoprotein A ratio has been reported to be normal (16,19) or decreased (14). In our study, this ratio, äs well äs the HDL-cholesterol/HDL-phospholipids and apolipoprotein A/HDL-phospholipids ratios, were normal for renal transplant patients.…”

“…The concentration of serum HDL-cholesterol was reported to be normal (14,16,27,34,40), decreased (28,30), or even increased (19,20). Serum apolipoprotein A concentration was reported to be normal (16) or increased (14,19). In our renal transplant patients, we have observed a normal serum concentration of HDLcholesterol and HDL-phospholipids and a slightly but significantly decreased concentration of apolipoprotein A.…”

“…Hypertriglyceridaemia and hypercholesterolaemia following renal transplantation have already been reported (20,27,28,30,34,39,40) and were also pbserved in the present study. The concentration of serum HDL-cholesterol was reported to be normal (14,16,27,34,40), decreased (28,30), or even increased (19,20). Serum apolipoprotein A concentration was reported to be normal (16) or increased (14,19).…”

“…(13) have shbwn that various levels of serum HDLcholesterol could be found for a given level of serum apolipoprotein A -I. As to renal transplant recipients, Jung et al (14) suggested that the changes in serum HDL composition often encountered in that setting should be taken into account when considering the pathogenesis of the high incidence of cardiovascular disease in these patients.…”

“…Only a few studies have been reported with determinations of serum apolipoprotein A (13)(14)(15)(16)(17)(18)(19)(20).…”