Lectin‐binding in premalignant lesions during submandibular gland carcinogenesis

Murase, Noriyasu; Takai, Yoshiaki; Hosaka, Matsuji; Asano, Kenichi; Mori, Masahiko

doi:10.1111/j.1600-0714.1984.tb01451.x

Cited by 16 publications

(4 citation statements)

References 20 publications

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“…It has been reported that .salivary gland myoepithelial cells stain for myosin, actomyosin (30,31), and actin (18). tions for FXiF, NCiF and leetins are reduced in proportion to the degree of degranulation of granular eonvoluted tubule cells and staining finally disappears (It), 12,24). Salivary gland growth factors such as E£(JF and NCiF, and leetin-bmding reaetions for sugar residues are thus useful as histochemical markers for the specific detection of granular convoluted tubule cells.…”

Section: Discussionmentioning

confidence: 99%

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Immunohistochemical localization of keratin in experimental carcinoma of the mouse submandibular gland

Takai

Murase

Hosaka

et al. 1986

J Oral Pathology Medicine

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An immunohistochemical survey of the distribution of keratin was studied in chemically induced carcinomas of the submandibular glands of mice. Initial signs of premalignant changes were degranulation of granular convoluted tubule cells and deposition of keratin protein in small limited areas of the degranulated cells. There was a gradual increase in the area showing keratin staining in altered tubule cells. Duct‐like and cystic structures stained intensely for keratin, as did squamous metaplastic epithelial cells. Induced carcinomas were variably keratinized. Basal layers of cells of squamous‐cell carcinomas displayed weak keratin staining, and spinous tumor cells and parakeratotic tumor cells showed somewhat increased levels of keratin staining. Some desquamated keratotic tumor cells stained intensely for keratin. Just as the localization of epidermal and nerve growth factors and lectin‐binding histochemistry have been used in studying tumorigenesis in the mouse submandibular gland, immunohistochemically detected keratin proved to be a useful marker of tumor cells of ductal segment origin.

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Section: Discussionmentioning

confidence: 99%

“…The granular convoluted tubule cells, target cells for chemical eareinogenesis, contain epidermal growth factor (EGF), nerve growth factor (N(iF) (K-IO), and eomplex carbohydrates whieh .specifically bind lectins (11). These particular substances in granular convoluted tubule eells were altered during eareinogenesis (12).…”

mentioning

confidence: 97%

Immunohistochemical localization of keratin in experimental carcinoma of the mouse submandibular gland

Takai

Murase

Hosaka

et al. 1986

J Oral Pathology Medicine

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“…Further they could play important role in immune system cell grow and cell dead. On the other hand, lectins could be considered as appropriate tools for monitoring of changes in spectra of glycosides present on surface of cell plasma membrane associated with transformed cell metabolism during cancer development (Murase et al 1984). It could be also applicable for monitoring of surface glycosides alteration during P-gp mediated MDR development (reviewed in Breier et al 2013).…”

Section: Application Of Lectins In Characterization Of Surface Sugarsmentioning

confidence: 99%

Lectin detection of cell surface saccharides remodeling induced by development of P-glycoprotein mediated multidrug resistance phenotype in L1210 leukemia cells

Šereš

Pavlíková

Sulová

et al. 2014

Acta Chimica Slovaca

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P-glycoprotein is an ATP dependent drug efflux pump the expression of which is responsible for strong depression of cell sensitivities to large group of structurally unrelated substances in neoplastic cells. We found that the expression of this protein in mice leukemia cells L1210 is associated with massive remodeling of cell surface saccharides. This remodeling is consistent with the alteration of cellular contents of UDP-sugars, glycogen and glycoproteins when P-gp positive and P-gp negative L1210 cell variants were compared. The current paper is focused on bringing the state of art information about this topic.

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“…While MuRASE et at. (29) showed that WGA binding was restricted to the mucous cells and the cystic contents in the mueoepidermoid carcinoma, we found that WGA can bind to all cell types and also to the cystic contents in this neoplasm.…”

Section: Discussionmentioning

confidence: 50%

Immunohistochemical and fluorescent microscopic study of histogenesis of salivary mucoepidermoid carcinoma

Hassanin

Ghosh

Das

et al. 1989

J Oral Pathology Medicine

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The purpose of the present investigation was to study the histogenesis of the mucoepidermoid carcinoma of the salivary glands. Eleven cases of mucoepidermoid carcinoma of the minor salivary glands and five of the major glands were extensively studied employing immunohistochemical and fluorescent microscopic techniques. Both the intermediate cells and the duct cells showed a rather similar pattern of reactivity for vimentin, actin and EMA. Also, the intermediate cells and the myoepithelial cells showed a similar reaction pattern for keratin and UGA-1. The intermediate, myoepithelial and duct cells shared a similar reaction pattern for desmin, myosin, CEA, and S-100 protein. However, the rest of the tumor markers studied (AFP, PNA and WGA) were found to be non contributary. We also found that the intermediate and to some extent the epidermoid tumor cells showed a positive reaction with Azophloxine GA, which is a selective stain for myoepithelial cells in the normal glands. Based on these findings, the duct cells, the myoepithelial cell in the normal glands and the intermediate cells of the mucoepidermoid carcinoma share certain similar characteristics. The intermediate cells may actually be a mixed population, some having characteristics of the myopithelial cells and others of duct cells. These findings are relevant to the possible role of the intermediate cell in the histogenesis of the mucoepidermoid carcinoma.

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Lectin‐binding in premalignant lesions during submandibular gland carcinogenesis

Cited by 16 publications

References 20 publications

Immunohistochemical localization of keratin in experimental carcinoma of the mouse submandibular gland

Immunohistochemical localization of keratin in experimental carcinoma of the mouse submandibular gland

Lectin detection of cell surface saccharides remodeling induced by development of P-glycoprotein mediated multidrug resistance phenotype in L1210 leukemia cells

Immunohistochemical and fluorescent microscopic study of histogenesis of salivary mucoepidermoid carcinoma

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