Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin

Zhang, Na; Ping, Qineng; Huang, Guihua; Xu, Wenfang; Cheng, Ye; Han, Xiuzhen

doi:10.1016/j.ijpharm.2006.07.026

Cited by 247 publications

(125 citation statements)

References 33 publications

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“…The findings of Zhang et al 20 were similar to ours in that the positive value of zeta potential of SLNs loaded with insulin and R 8 (R 8 -Ins-SLNs) confirmed that a certain amount of R 8 (a type of CPPs) molecule or cationic group of R 8 molecule was exposed on the surface of the SLNs. In addition, the stearyl group of Ste-R 6 L 2 can attach to the N-terminal of the peptide and act as an anchor to the lipid surface of the nanoparticles, which leaves the Ste-R 6 L 2 freely attached.…”

Section: Discussionsupporting

confidence: 80%

“…20,31 Ste-R 6 L 2 is a kind of CPP, which has short amino acid sequences that are mainly composed of arginine and leucine. Ste-R 6 L 2 has cationic properties and thus it can easily adhere to the NLC surfaces on the basis of electrostatic interactions.…”

Section: Discussionmentioning

confidence: 99%

“…16 CPPs are rich in basic amino acids such as arginine, lysine, and leucine, and are thought to be absorbed predominantly via endocytosis and translocation. 17 These peptides are capable of internalizing electrostatically or covalently bound, biologically active cargoes such as several proteins, 18 oligonucleotides, 19 solid lipid nanoparticles (SLNs), 20 and liposomes 21 with high efficiency and low toxicity. 22,23 One study showed that CPP-coated SLNs could be a promising per-oral carrier for oral administration of insulin.…”

Section: Introductionmentioning

confidence: 99%

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Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine

Chen

Yuan²,

Zhou³

et al. 2012

IJN

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Purpose: To develop nanostructured-lipid carriers (NLCs) coated with cell-penetrating peptides (CPP) for improving the oral bioavailability of tripterine. Methods: We prepared CPP-coated tripterine-loaded NLCs (CT-NLCs) by using a solvent evaporation method, and determined their physical properties. In vitro drug release was determined by using a dialysis bag diffusion technique, and intestinal toxicity was evaluated by performing MTT assay using Caco-2 cells. In vivo absorption was studied in an in situ rat intestinal perfusion model, and oral bioavailability was examined in beagles. Results: The average particle size, zeta potential, and encapsulation efficiency of the optimized CT-NLCs were 126.7 ± 9.2 nm, 28.7 ± 3.4 mV, and 72.64% ± 1.37%, respectively. The CT-NLCs showed a controlled release profile in vitro and had significantly lower intestinal cytotoxicity than the tripterine solution (P , 0.05). The absorption levels of tripterine from the CT-NLCs in the rat duodenum and jejunum were markedly higher than with tripterine-loaded NLCs without the CPP coating (T-NLCs), and with tripterine solution. Pharmacokinetic study showed that the maximum concentration of the CT-NLCs was greater than that of the T-NLCs and tripterine suspension, and that the time to maximum concentration of the CT-NLCs as well as the T-NLCs, was longer than that of the tripterine suspension. The relative oral bioavailability of the CT-NLCs compared to that of tripterine suspension and T-NLCs were 484.75% and 149.91% respectively. Conclusion: The oral bioavailability of tripterine is dramatically increased by CT-NLCs. Therefore, CT-NLCs seem to be a promising carrier for oral delivery of tripterine.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine

Chen

Yuan²,

Zhou³

et al. 2012

IJN

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“…The oral bioavailability was still unacceptably low. The improvement of the drug entrapment efficiency and utilization of protease inhibitors were suggested to increase the bioavailability further (32).…”

Section: Slnsmentioning

confidence: 99%

Nanocarriers: Novel Approaches to Oral Delivery of Insulin

Özer¹,

Kerımoğlu²,

Uğurlu³

2017

Clin Exp Health Sci

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“…Wheat germ agglutinin binds (WGA) specifically to cell membranes and is taken up into cells by receptor-mediated endocytosis [28]. Zhang et al [29] …”

Section: Solid Lipid Nanoparticles (Sln)mentioning

confidence: 99%

Oral Delivery of Insulin: Novel Approaches

Elsayed¹

2012

Recent Advances in Novel Drug Carrier Systems

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Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin

Cited by 247 publications

References 33 publications

Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine

Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine

Nanocarriers: Novel Approaches to Oral Delivery of Insulin

Oral Delivery of Insulin: Novel Approaches

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