Lectins as defence molecules in vertebrates and invertebrates

Arason, G J

doi:10.1006/fsim.1996.0029

Cited by 112 publications

(63 citation statements)

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“…Among total serum proteins, globulins correspond to proteins present in blood responsible for the organism's defense, such as immunoglobulins, proteins of the complement activated by alternative pathways, acute phase proteins, cytokines, lysozyme, transferrin and lectins. In the present study the increase in total serum protein and globulin indicate the raise in protective proteins after the challenge and can be correlated to the serum bactericidal activity (Murray and Fletcher, 1976;Arason, 1996, Ellis 1999, 2001, Magnadottir, 2006Maqsood et al, 2009 …”

Section: Discussionsupporting

confidence: 52%

“…In addition, antiproteases, such as lectins, are blood proteins which act on the proteolytic compound of bacteria responsible for the lysis of fish tissue. Lectins generate pathogen agglutination due to its high affinity to certain carbohydrates on the bacteria wall (Bullen and Griffiths, 1987;Arason, 1996;Bayne and Gerwick, 2001;Stafford and Belosevic, 2003;Salinas et al, 2011).…”

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confidence: 99%

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Serum bactericidal activity as indicator of innate immunity in pacu Piaractus mesopotamicus (Holmberg, 1887)

Biller-Takahashi

Takahashi

Pilarski³

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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The immune system of teleost fish has mechanisms responsible for the defense against bacteria through protective proteins in several tissues. The protein action can be evaluated by serum bactericidal activity and this is an important tool to analyze the immune system. Pacu, Piaractus mesopotamicus, is one of the most important fish in national aquaculture. However there is a lack of studies on its immune responses. In order to standardize and assess the accuracy of the serum bactericidal activity assay, fish were briefly challenged with Aeromonas hydrophila and sampled one week after the challenge. The bacterial infection increased the concentration of protective proteins, resulting in a decrease of colony-forming unit values expressed as well as an enhanced serum bactericidal activity. The protocol showed a reliable assay, appropriate to determine the serum bactericidal activity of pacu in the present experimental conditions.

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Section: Discussionsupporting

confidence: 52%

mentioning

confidence: 99%

Serum bactericidal activity as indicator of innate immunity in pacu Piaractus mesopotamicus (Holmberg, 1887)

Biller-Takahashi

Takahashi

Pilarski³

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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“…The presence of multiple CRDs in combination with other protein domains, enable not only the recognition of carbohydrates on the surface of potential pathogens, but also effector functions including agglutination, immobilization and opsonization of potential pathogens, and activation of the complement pathway [6][7][8]. Based on their primary structure, requirement of divalent cations, and structural fold, animal lectins have been classified into several families, such as C-, P-, and I-types, galectins, and pentraxins [6,9]. Lectins have been isolated from serum, plasma, mucus and eggs from several fish species but their biological function(s) have only been partially elucidated [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Isolation and characterization of a fish F-type lectin from gilt head bream (Sparus aurata) serum

Cammarata

Benenati

Odom

et al. 2007

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…1,[5][6][7] Lectins are involved in a variety of key biological processes ranging from development to immune responses. 1,[7][8][9][10][11] The roles of lectin-carbohydrate interactions in self/non-self recognition in early development and innate immunity of vertebrates has been well documented. 1,[7][8][9][10][11] In some ("chimeric" or "mosaic") lectins, the combination of one or multiple CRDs with distinct functional domains enable additional effector functions including opsonization and phagocytosis, and activation of the complement pathway.…”

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confidence: 99%

“…1,[7][8][9][10][11] The roles of lectin-carbohydrate interactions in self/non-self recognition in early development and innate immunity of vertebrates has been well documented. 1,[7][8][9][10][11] In some ("chimeric" or "mosaic") lectins, the combination of one or multiple CRDs with distinct functional domains enable additional effector functions including opsonization and phagocytosis, and activation of the complement pathway. 12 It is now well established that protein-carbohydrate interactions constitute the basis of mechanisms mediating signaling functions, cell communication, and self/non-self recognition that are critical in the establishment and maintenance of highly specific mutualistic associations in organism-microbe complexes.…”

Section: Introductionmentioning

confidence: 99%

Evolution and Immune Function of Fish Lectins

Cammarata¹,

Parisi²,

Vasta³

2016

Lessons in Immunity

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Any queries or remarks that have arisen during the processing of your manuscript are listed below and are highlighted by flags in the proof. (AU indicates author queries; ED indicates editor queries; and TS/TY indicates typesetter queries.) Please check your proof carefully and answer all AU queries. Mark all corrections and query answers at the appropriate place in the proof using on-screen annotation in the PDF file. For a written tutorial on how to annotate PDFs, click http://www.elsevier.com/__data/assets/ pdf_file/0007/98953/Annotating-PDFs-Adobe-Reader-9-X-or-XI.pdf. A video tutorial is also available at http://www.screencast. com/t/9OIDFhihgE9a. Alternatively, you may compile them in a separate list and tick off below to indicate that you have answered the query. Please return your input as instructed by the project manager. Location in articleQuery / remark AU1, page 244 Please provide the expansion for genus names "S. purpuratus" and "C. intestinalis" in the sentence "In contrast, the N…". ■ AU4, page 250 Please check the term "conCL-s" mentioned in the sentence "In the latter, conCL-s…". ■ AU5, page 243The citation 'Ogawa et al.,25 ' in the legend of To protect the rights of the author(s) and publisher we inform you that this PDF is an uncorrected proof for internal business use only by the author(s), editor(s), reviewer(s), Elsevier and typesetter TNQ Books and Journals Pvt Ltd. It is not allowed to publish this proof online or in print. This proof copy is the copyright property of the publisher and is confidential until formal publication. 10018-BALLARIN-9780128032527Chapter 18 Evolution and Immune Function of Fish LectinsMatteo Cammarata, Maria G. Parisi University of Palermo, Palermo, Italy Gerardo R. Vasta University of Maryland School of Medicine, Baltimore, MD, United States c0018 INTRODUCTIONThe term "lectin" is commonly used to encompass a wide variety of carbohydrate-binding proteins, widely distributed in viruses, prokaryotes, and eukaryotes. 1 The first invertebrate lectins were described in the early 1900s in the snail Helix pomatia, 2 the horseshoe crab Limulus polyphemus, 3 and the lobster Homarus americanus. 3 Among the vertebrates, Watkins and Morgan 4 first described an l-fucose-specific lectin in the European eel Anguilla anguilla, which led to the discovery of the carbohydrate nature of the H blood substance. Animal lectins are grouped in various molecular families, differing in carbohydrate recognition domain (CRD) structure and organization. 1,[5][6][7] Based on their CRD sequence motifs and cation requirements, animal lectins can be categorized in several families, such as C-type lectins (CTLs), galectins (formerly S-type lectins), rhamnose-binding lectins (RBLs), F-type lectins (FTLs), X-type lectins (XTLs), I-type lectins, P-type lectins, and pentraxins. 1,[5][6][7] Lectins are involved in a variety of key biological processes ranging from development to immune responses. 1,[7][8][9][10][11] The roles of lectin-carbohydrate interactions in self/non-self recognition in early dev...

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Lectins as defence molecules in vertebrates and invertebrates

Cited by 112 publications

References 47 publications

Serum bactericidal activity as indicator of innate immunity in pacu Piaractus mesopotamicus (Holmberg, 1887)

Serum bactericidal activity as indicator of innate immunity in pacu Piaractus mesopotamicus (Holmberg, 1887)

Isolation and characterization of a fish F-type lectin from gilt head bream (Sparus aurata) serum

Evolution and Immune Function of Fish Lectins

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