Lectins of<i>Mycobacterium tuberculosis</i>– rarely studied proteins

Kolbe, Katharina; Veleti, Sri Kumar; Reiling, Norbert

doi:10.3762/bjoc.15.1

Cited by 9 publications

(9 citation statements)

References 125 publications

(124 reference statements)

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“…There is evidence to suggest that lectin-host interactions in Mtb are a potential mechanism to facilitate the establishment of infection. In this sense, it has been shown that lectins derived from Mtb could play an important role in infection in vivo ( Nogueira et al, 2010 ; Kolbe et al, 2019 ). It is likely that the deletion found in the Rv1419 gene in low prevalence isolates altered this host-pathogen interaction and therefore the ability of the mycobacterium to establish an infectious process.…”

Section: Discussionmentioning

confidence: 99%

Pan-genome association study of Mycobacterium tuberculosis lineage-4 revealed specific genes related to the high and low prevalence of the disease in patients from the North-Eastern area of Medellín, Colombia

Hurtado-Páez

Zuluaga²,

Isaza³

et al. 2023

Front. Microbiol.

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Mycobacterium tuberculosis (Mtb) lineage 4 is responsible for the highest burden of tuberculosis (TB) worldwide. This lineage has been the most prevalent lineage in Colombia, especially in the North-Eastern (NE) area of Medellin, where it has been shown to have a high prevalence of LAM9 SIT42 and Haarlem1 SIT62 sublineages. There is evidence that regardless of environmental factors and host genetics, differences among sublineages of Mtb strains play an important role in the course of infection and disease. Nevertheless, the genetic basis of the success of a sublineage in a specific geographic area remains uncertain. We used a pan-genome-wide association study (pan-GWAS) of 47 Mtb strains isolated from NE Medellin between 2005 and 2008 to identify the genes responsible for the phenotypic differences among high and low prevalence sublineages. Our results allowed the identification of 12 variants in 11 genes, of which 4 genes showed the strongest association to low prevalence (mmpL12, PPE29, Rv1419, and Rv1762c). The first three have been described as necessary for invasion and intracellular survival. Polymorphisms identified in low prevalence isolates may suggest related to a fitness cost of Mtb, which might reflect a decrease in their capacity to be transmitted or to cause an active infection. These results contribute to understanding the success of some sublineages of lineage-4 in a specific geographical area.

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Section: Discussionmentioning

confidence: 99%

Pan-genome association study of Mycobacterium tuberculosis lineage-4 revealed specific genes related to the high and low prevalence of the disease in patients from the North-Eastern area of Medellín, Colombia

Hurtado-Páez

Zuluaga²,

Isaza³

et al. 2023

Front. Microbiol.

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“…1, top left). Therefore, the role of Mtb glycosylation pattern and its impact in the recognition by the host immune system is still poorly clarified [24]. These evidence highlight the importance of further studies focused on how Mtb glycosylation regulate host–pathogen interactions and Mtb pathogenesis, envisioning novel strategies to stop the progression of tuberculosis, a disease that remains without cure.…”

Section: Pathogen‐associated Glycans In Infectious Diseases: a Source...mentioning

confidence: 99%

“…The recognition of ManLAM by DC-SIGN is associated with the ManLam capture and internalization by DC-SIGN on immature DCs, which is then targeted to lysosomes. This process results in IL-10 secretion, leading to suppression of DCs function [17,18], phagosome maturation of macrophages (MΦ) and CD4 + T-cell activation [24,25]. In fact, loss of O-mannosylation in these bacteria results in lower infection and proliferation rate in the host [26], as well as lower Tcell antigenicity [27], which highlight the relevance of ManLam glycans for Mtb immune escape.…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Glycans as a key factor in self and nonself discrimination: impact on the breach of immune tolerance

et al. 2022

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Glycans are carbohydrates that are made by all organisms and covalently conjugated to other biomolecules. Glycans cover the surface of both human cells and pathogens and are fundamental to defining the identity of a cell or an organism, thereby contributing to discriminating self from nonself. As such, glycans are a class of ‘Self‐Associated Molecular Patterns’ that can fine‐tune host inflammatory processes. In fact, glycans can be sensed and recognized by a variety of glycan‐binding proteins (GBP) expressed by immune cells, such as galectins, siglecs, and C‐type lectins, which recognize changes in the cellular glycosylation, instructing both pro‐inflammatory and anti‐inflammatory responses. In this review, we introduce glycans as cell‐identification structures, discussing how glycans modulate host–pathogen interactions and how they can fine‐tune inflammatory processes associated with infection, inflammation and autoimmunity. Finally, from the clinical standpoint, we discuss how glycoscience research can benefit life sciences and clinical medicine by providing a source of valuable biomarkers and therapeutic targets for immunity.

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“…Moreover, galectin-3 interacts with the master regulator KRAS, which, if mutated, is one of the main driver of various cancer types (Shalom-Feuerstein et al, 2008). Finally, lectins are also employed by highly pathogenic bacteria such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, and uropathogenic Escherichia coli to facilitate cell adhesion and entry (Mitchell et al, 2002;Imberty et al, 2008;Hartmann and Lindhorst, 2011;Kolbe et al, 2019).…”

Section: Functions Traditionally Attributed To the Glycocalyxmentioning

confidence: 99%

The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation

Möckl

2020

Front. Cell Dev. Biol.

169

126

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All cells in the human body are covered by a dense layer of sugars and the proteins and lipids to which they are attached, collectively termed the "glycocalyx." For decades, the organization of the glycocalyx and its interplay with the cellular state have remained enigmatic. This changed in recent years. Latest research has shown that the glycocalyx is an organelle of vital significance, actively involved in and functionally relevant for various cellular processes, that can be directly targeted in therapeutic contexts. This review gives a brief introduction into glycocalyx biology and describes the specific challenges glycocalyx research faces. Then, the traditional view of the role of the glycocalyx is discussed before several recent breakthroughs in glycocalyx research are surveyed. These results exemplify a currently unfolding bigger picture about the role of the glycocalyx as a fundamental cellular agent.

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Lectins ofMycobacterium tuberculosis– rarely studied proteins

Cited by 9 publications

References 125 publications

Pan-genome association study of Mycobacterium tuberculosis lineage-4 revealed specific genes related to the high and low prevalence of the disease in patients from the North-Eastern area of Medellín, Colombia

Pan-genome association study of Mycobacterium tuberculosis lineage-4 revealed specific genes related to the high and low prevalence of the disease in patients from the North-Eastern area of Medellín, Colombia

Glycans as a key factor in self and nonself discrimination: impact on the breach of immune tolerance

The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation

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