LED&amp;Paper-based analytical device for phosphatemia/calcemia diagnostics☆

Fiedoruk-Pogrebniak, Marta; Koncki, Robert

doi:10.1016/j.jpba.2020.113321

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…Detection of Pseudomonas aeruginosa (PA) in human saliva and tap water using electrochemical detection on paper [35] Clinical diagnostics Simultaneous detections of orthophosphate and calcium ions in human serum for hyperphosphatemia diagnostics using paper-based device with LED-based fluorescence detectors [36] Clinical diagnostics Detection of two steroids including dexamethasone and prednisolone in herbal medicine samples using electrochemical detection on paper [37] Environmental analysis Detection of total ammonia in freshwaters for evaluation of water quality using acid-base indicator screening on paper and colorimetric-based detection [38] Environmental analysis Simultaneous detections of glycerol, magnesium, and calcium in biodiesel samples using liquid-liquid microextraction coulple with colorimetric-based detection on paper [39]…”

Section: Clinical Diagnosticsmentioning

confidence: 99%

Development of sensing platforms using bulk optode technique for detection of silver and mercury ions

Phichi

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This research described�new analytical devices for Ag+ and Hg2+ detection using bulk optode technique. The optode containing 25,27-di(benzothiazolyl)-26,28-hydroxycalix[4]arene (CU1) as an ion-selective ionophore, chromoionophore XIV as a lipophilic pH indicator, and KTpClPB as an ion-exchanger was prepared and used as a sensing agent in the proposed devices. The optode sensors responded to Ag+ and Hg2+ by changing the color from blue to yellow. The colorimetric-based detection was carried out by using the proposed paper-based analytical device. A simple fabrication method was performed by simply dropping the cocktail onto the filter paper, and the detection method was easily performed by immersing the paper strip into the sample solutions. �In this platform, the dual detection of Ag+ and Hg2+ in their mixed solutions was achieved by adding EDTA and NaCl as masking agents, respectively. Additionally, to demonstrate a truly instrument-free optode sensor without the need of any electronic equipment, the distance-based detection was proposed by using the thread-based analytical device. The optode nanosphere with 110 nm in diameters was successfully prepared and incorporated onto the surface of polyester thread by a simple manual pipetting, and the detection method was easily performed by repeatedly dropped sample solutions onto the thread. In this platform, the Hg2+ detection on thread-based device was exhibited. The distances of the color change correlated to the Hg2+ concentrations in sample solutions, so the detection method was easily performed by measuring the length of the color change along the thread with a ruler. Finally, the proposed devices were successfully applied to determine the amount of Ag+ and Hg2+ in real samples, and the results were in agreement with the values obtained from ICP-OES.

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