Left and Right Ventricular Function Is Impaired in Behçet's Disease

Yavuz, Bünyamin; Sahiner, L.; Akdoğan, Ali; Abalı, Gülcan; Aytemir, Kudret; Tokgözoğlu, Lâle; Kalyoncu, Umut; Karadağ, Ömer; Kiraz, Sedat; Ertenli, İhsan; Çalgünerı, Meral; Nazli, Nasıh

doi:10.1111/j.1540-8175.2006.00301.x

Cited by 21 publications

(12 citation statements)

References 17 publications

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“…Impaired LVDF in patients with BD was also documented using the lateral mitral annular velocities. 14 In agreement with our findings, Tunc et al 8 detected normal LVDF with no significant difference in diastolic parameters between patients and controls using the TDI and transmitral velocities. Similar findings were also documented in two previous studies.…”

Section: Discussionsupporting

confidence: 81%

“…6,7 While some studies suggested that BD does not result in impaired left ventricular diastolic function (LVDF), [8][9][10] others have documented impaired LVDF. [11][12][13][14] One study suggested that the incidence of left ventricular diastolic dysfunction (LVDD) in BD is related to the geographic distribution of patients. 12 In a previous study, the occurrence of intracardiac thrombi, aortic valve regurgitation, and pericardial effusion in Egyptian patients with BD were documented.…”

mentioning

confidence: 99%

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Assessment of Left Ventricular Diastolic Function in Egyptian Patients With Behçet’s Disease

et al. 2016

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Objectives: This study aims to evaluate left ventricular diastolic function in Egyptian patients with Behçet's disease using variable echocardiographic parameters by combining both transmitral and tissue Doppler velocities to overcome the occasional false interpretation of preload dependent transmitral parameters and to detect the correlation between various left ventricular diastolic parameters and different disease manifestations. Patients and methods: Forty patients (35 males, 5 females; mean age 31±8 years; range 19 to 52 years) with Behçet's disease and 32 age-and sexmatched healthy controls (26 males, 6 females; mean age 28±6 years; range 19 to 60 years) were enrolled. Left ventricular diastolic function was assessed using an algorithm that combined transmitral and tissue Doppler derived parameters. Results: Mean disease duration of the patients was 7.4±6 years. Left and right ventricular systolic function was normal in both groups. The transmitral E/A was <1 in six patients (15%). There was no difference between patients and controls regarding the other left ventricular diastolic parameters. Compared to patients with an E/A ratio >1, patients with E/A <1 were significantly older and had a longer disease duration (p=0.001 and p<0.001, respectively). All the other echocardiographic parameters in both groups were comparable. Conclusion: Egyptian patients with Behçet's disease have normal left ventricular diastolic function regardless of disease duration and activity.

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Section: Discussionsupporting

confidence: 81%

mentioning

confidence: 99%

Assessment of Left Ventricular Diastolic Function in Egyptian Patients With Behçet’s Disease

et al. 2016

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“…Measurements were focused on the systolic myocardial wave, the early-diastolic and end-diastolic myocardial waves. Usually, several cardiac cycles were acquired, and the best two consecutive ones were analyzed and averaged [15]. …”

Section: Methodsmentioning

confidence: 99%

Elevation of B-Type Natriuretic Peptide Level in Asymptomatic Hepatitis B Virus-Positive Patients Is Not Associated with Abnormalities of Cardiac Function

Küçükazman¹,

Ata²,

Yavuz

et al. 2011

Med Princ Pract

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Objectives: To compare B-type natriuretic peptide (BNP) and echocardiographic parameters in patients with hepatitis B virus (HBV) and healthy control subjects. Subjects and Methods: 52 consecutive patients with HBV and 47 healthy controls were examined. All subjects underwent transthoracic echocardiography after a complete medical history and laboratory examination including BNP, C-reactive protein (CRP) and high-sensitivity CRP (hsCRP). Results: Demographic characteristics were similar in patients with HBV and the control group. No significant difference was found in conventional Doppler and tissue Doppler parameters between the two groups. BNP levels were significantly higher in patients with HBV [6.5 ng/l (range 0.5-85.2)] than controls [4.3 ng/l (range 0.5-18.3)], p = 0.039. hsCRP [3.25 mg/l (0.02-40.2) vs. 0.5 mg/l (0.02-8.0)] levels were significantly higher in patients with HBV than control subjects (p < 0.001). Conclusion: Patients with HBV had higher BNP, CRP, and hsCRP levels than controls. Echocardiographic findings were similar in both groups. This slight BNP elevation in HBV patients may be related to chronic inflammation due to HBV.

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“…158 Potential explanations for this dysfunction include the possibility of primary myocardial disease, disturbance of the coronary microcirculation, or the presence of silent ischemia. 157 In one recent study, no differences were found in left ventricular function in systole and diastole at rest and with exercise in patients as compared to healthy control subjects. 159 This discrepancy of the reported studies may be due to the patient selection or to the sensitivity of the assessment methods.…”

Section: Pericarditismentioning

confidence: 96%

“…156 In the first study to use pulsed wave Doppler tissue echocardiography, ventricular diastolic function was found to be abnormal in BD patients as compared to control subjects. 157 Diastolic dysfunction was reported in 37% of patients using transthoracic and multiplane transesophageal echocardiography. 158 Potential explanations for this dysfunction include the possibility of primary myocardial disease, disturbance of the coronary microcirculation, or the presence of silent ischemia.…”

Section: Pericarditismentioning

confidence: 98%

Behçet’s disease: an update on pathogenesis, diagnosis and management of vascular involvement

Kaklamanis

Calamia

2010

Rheumatol Rep

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The objective of this review is to summarize reports of the prevalence, clinical presentation, diagnostic methodology and treatment of vasculitic manifestations of Behçet’s disease (BD). We performed a literature search on vasculitis in BD. Articles were selected which provided insight into the pathogenesis and clinical aspects of vasculitis. Vasculitis underlies many of the clinical features of BD. Small vessel vasculitis is often found in the pathology of the mucocutaneous manifestations of BD. Large vessel vasculitis has been reported in 15-40% of BD patients. Ultrasound, angiography and tomography are applied to confirm the diagnosis when venous involvement is suspected. Endothelial dysfunction plays a role in the pathogenesis of disease. Peripheral arterial involvement in BD occurs in the form of arterial occlusion or aneurysms. Pulmonary arterial involvement is often life-threatening. The cause of cardiac vascular involvement requires an aggressive diagnostic approach. Corticosteroids and immunosuppressive agents have been used successfully in the early stage of large vessel disease and should be used as an adjunct to surgery. An increasing amount of data is available regarding the role of anti-tumor necrosis factor (TNF) agents for the treatment of BD. Anticoagulant therapy may be hazardous in patients with aneurysmal dilatation of the pulmonary vascular tree and is not effective in the treatment of venous thrombosis. Inflammation of small and large vessels is very frequent in BD. Both arteries and veins may be involved. Early recognition and appropriate management of large vessel vasculitis in BD is essential to reduce associated morbidity and mortality

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Left and Right Ventricular Function Is Impaired in Behçet's Disease

Abstract: We demonstrated that myocardial velocities, were affected in patients with BD. Therefore, we conclude that right and left ventricular function is impaired in patients with BD.

Cited by 21 publications

References 17 publications

Assessment of Left Ventricular Diastolic Function in Egyptian Patients With Behçet’s Disease

Assessment of Left Ventricular Diastolic Function in Egyptian Patients With Behçet’s Disease

Elevation of B-Type Natriuretic Peptide Level in Asymptomatic Hepatitis B Virus-Positive Patients Is Not Associated with Abnormalities of Cardiac Function

Behçet’s disease: an update on pathogenesis, diagnosis and management of vascular involvement

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