Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation

Ko, Darae

doi:10.1161/circep.115.002634

Cited by 1 publication

(1 citation statement)

References 21 publications

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“…47 Whereas concerns regarding later ischemic strokes remain, a patient-level data meta-analysis suggests potential benefit because of decreased bleeding rates in the long-term. 48,49 Implantation success rates are currently very high (>95%), but significant adverse peri-procedural events, such as tamponade, may occur. 50,51 Reported complication rates of the procedure vary between registries and RCTs and have been shown to decrease over time with operator experience.…”

Section: Left Atrial Appendage Occlusion and Early Rhythm-control The...mentioning

confidence: 99%

New Avenues for Optimal Treatment of Atrial Fibrillation and Stroke Prevention

Marchis

Sposato

Kühne

et al. 2021

Stroke

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One in 3 individuals free of atrial fibrillation (AF) at index age 55 years is estimated to develop AF later in life. AF increases not only the risk of ischemic stroke but also of dementia, even in stroke-free patients. In this review, we address recent advances in the heart-brain interaction with focus on AF. Issues discussed are (1) the timing of direct oral anticoagulants start following an ischemic stroke; (2) the comparison of direct oral anticoagulants versus vitamin K antagonists in early secondary stroke prevention; (3) harms of bridging with heparin before direct oral anticoagulants; (4) importance of appropriate direct oral anticoagulants dosing; (5) screening for AF in high-risk populations, including the role of wearables; (6) left atrial appendage occlusion as an alternative to oral anticoagulation; (7) the role of early rhythm-control therapy; (8) effect of lifestyle interventions on AF; (9) AF as a risk factor for dementia. An interdisciplinary approach seems appropriate to address the complex challenges posed by AF.

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