Left Atrial Myxoma Presenting as an Embolic Shower: A Case Report and Review of Literature

Bernatchez, Julien; Gaudreault, Valérie; Vincent, Gabriel; Rhéaume, Pascal

doi:10.1016/j.avsg.2018.04.024

Cited by 21 publications

(17 citation statements)

References 33 publications

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“…Embolic symptoms would be determined by the site of the embolization, which are essentially decided by the position of the myxomas. Left-sided myxoma may cause peripheral embolism [ 11 , 12 ] such as stroke, while right-sided myxoma can potentially cause pulmonary embolism [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary embolism [13] Peripheral embolism [11,12] Cerebral/mesenteric/limb ischemia Constitutional Fever, Infected cardiac myxoma, weight loss, etc. [2] Onset [14] Late onset Early onset Treatment Surgical resection Timely surgical resection is always necessary for all myxomas [15,16]…”

Section: Embolicmentioning

confidence: 99%

“…Moreover, the clinical symptoms of cardiac myxomas vary greatly on a case-to-case basis [ 2 – 5 ], largely depending on their size, location and mobility. A peripheral embolic event in patients without any conventional risk factors may prompt a suspicion of a left-sided cardiac myxoma [ 6 ]; however, the manifestations of a right-sided cardiac myxoma are often uncharacteristic, leading to delayed diagnosis, treatment and unfavorable outcomes [ 4 , 5 ]. Herein we report a very rare case of a giant right ventricular myxoma presented with right heart failure with systemic congestion.…”

Section: Introductionmentioning

confidence: 99%

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Giant right ventricular myxoma presenting as right heart failure with systemic congestion: a rare case report

Chen

Yang

2021

BMC Surg

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Background Myxoma is an uncommon disease and its symptoms vary greatly depending on size, location and mobility. Right-sided myxoma, especially right ventricular myxoma, is much rarer, and the symptoms are alien and uncharacteristic. The lack of understandings poses challenges to prompt diagnosis and timely treatment. Case presentation A 44-year-old female patient was diagnosed with giant right ventricular tumor. Right heart failure and systemic congestion caused by right ventricular outflow tract obstruction were observed on this case. Surgery was performed to excise the mass which was measured at 9.5 * 5.0 cm and confirmed as myxoma pathologically. Conclusions Right-side myxoma is easy to be unnoticed due to its low incident rate and atypical symptoms. Delay in surgical intervention might cause unrecoverable complications. More comprehensive understanding of the symptoms is expected to help improving the diagnose and treat of right-sided myxoma.

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Section: Discussionmentioning

confidence: 99%

Section: Embolicmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Giant right ventricular myxoma presenting as right heart failure with systemic congestion: a rare case report

Chen

Yang

2021

BMC Surg

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“…Myxoma is the most common type of primary cardiac tumor in adults [1]. About 75% of cardiac myxoma originates in the left atrium, and only a few are located in the right atrium or ventricles [2]. The fragile and highly mobile myxoma can result in serious systemic embolization and left ventricular inflow tract obstruction.…”

Section: Introductionmentioning

confidence: 99%

Occult cardiac myxoma with glandular structure detected by transesophageal echocardiography in a patient with cerebral infarction

Liu

Yang

et al. 2020

Preprint

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A previously healthy 68-year-old woman with abrupt weakness in her left limbs underwent transthoracic echocardiography for paroxysmal atrial fibrillation, which showed normal left ventricular function and no abnormalities except for left atrial dilation. However, transesophageal echocardiogram showed two leaflet-shaped loose left atrial masses were attached to the atrial septum near the oval fossa. Further CDFI found a few small vessels at the base, confirming the atrial myxoma. Surgery was performed to resect the intracardiac mass, and the histologic examination showed cardiac myxoma with glandular structure.

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“…[ 2 ] Imaging materials, including transthoracic echocardiogram (TTE), cardiac computed tomogram (CT) and cardiac magnetic resonance images (MRI), are pivotal in the diagnosis, management guidance, and surveillance of cardiac myxoma. [ 3 ] Surgical excision of the cardiac myxomas is the established definitive treatment and is highly efficacious. [ 4 ] Previous reports on molecular etiology of CNC have identified that mutation of the cAMP-dependent protein kinase A (PKA) regulatory (R) subunit 1 ( PRKAR1A ) gene was associated with CNC.…”

Section: Introductionmentioning

confidence: 99%

Identification of a PRKAR1A mutation (c.491_492delTG) in familial cardiac myxoma

Liu

Zhang

et al. 2019

Medicine

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Rationale:Cardiac myxoma is the most common cardiac neoplasm. Currently, there are not many reports on familial cardiac myxoma. Herein, we reported 2 first-degree relatives with left atrial myxoma.Patient concerns:A 20-year-old female was admitted in our hospital for lapsing into a coma for 24 hours, and was diagnosed with recurrent left atrial cardiac myxoma. The patient's father also had a history of cardiac myxoma.Diagnosis:The patient was diagnosed with left atrial myxoma using transthoracic echocardiography (TTE). Whole exome sequencing (WES) identified a p.Val164Aspfs (c.491-492delTG) mutation in the cAMP-dependent protein kinase A (PKA) regulatory (R) subunit 1 (PRKAR1A) gene for both the proband and her father, but not in her uncle and brother, who had not shown manifestation of cardiac myxoma by the time of this report.Interventions:The myxoma resection was performed following the standard procedure of open chest surgery.Outcomes:The tumor was successfully removed along with the tuberculum. The patient recovered well and was discharged home. No recurrence occurred during 1-year follow-up.Lessons:Our findings suggest that PRKAR1A mutation (c.491_492delTG) may be associated with cardiac myxoma, and genetic counseling and specific locus mutation tests may contribute to assessing the risk of cardiac myxoma.

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Left Atrial Myxoma Presenting as an Embolic Shower: A Case Report and Review of Literature

Cited by 21 publications

References 33 publications

Giant right ventricular myxoma presenting as right heart failure with systemic congestion: a rare case report

Giant right ventricular myxoma presenting as right heart failure with systemic congestion: a rare case report

Occult cardiac myxoma with glandular structure detected by transesophageal echocardiography in a patient with cerebral infarction

Identification of a PRKAR1A mutation (c.491_492delTG) in familial cardiac myxoma

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