Left atrial myxoma with concomitant coronary artery stenosis: comprehensive diagnosis and treatment

Ciechański, Erwin; Ciechański, Krystian; Szponar, Jarosław; Kołataj, P; Szczasny, Marcin; Główniak, Andrzej; Szumiło, Justyna

doi:10.12775/jehs.2022.12.02.008

Cited by 1 publication

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Digoxin has positive inotropic and negative chronotropic effects on the heart, and is primarily used in treating heart failure and tachydysrhythmias [ 1 ]. In clinical practice, there is a high probability of accidental intoxication with digitalis owing to the narrow therapeutic window [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Successful management of massive digoxin overdose using DIGIFab and therapeutic plasma exchange: a case report

Alhussein,

Alamri,

Alhashem

et al. 2024

J Med Case Reports

View full text Add to dashboard Cite

Background Despite the efficacy and safety of DIGIFab, it is relatively expensive and has limited availability. In addition, alternative interventions, such as therapeutic plasma exchange, may need to be considered in massive digoxin overdoses. Although few case reports describe its efficacy. Case presentation We report a case of a 17-year-old white male patient brought by family members to our emergency department in Riyadh, Saudi Arabia. After intentionally ingesting 48 mg of digoxin tablets to commit suicide, the patient’s initial digoxin serum level was 8.04 ng/mL. The patient was resuscitated in the emergency department. After admission to the intensive care unit, the patient underwent therapeutic plasma exchange, because of insufficient DIGIFab doses. Afterward, the serum digoxin levels drastically decreased, and his symptoms reverted. The patient was successfully managed and discharged 7 days after admission. Conclusion Despite insufficient evidence and a limited number of case reports describing the use of extracorporeal treatment in digoxin overdose, we noted the significant impact of therapeutic plasma exchange on our patient. However, therapeutic plasma exchange’s use in routine treatment requires stronger evidence to confirm its benefits.

show abstract

Section: Introductionmentioning

confidence: 99%

“…However, the number of reported suicide cases using digoxin was significant [ 3 – 6 ]. Compared with other medications, massive digoxin intoxication after a suicide attempt is uncommon [ 1 ].…”

Section: Introductionmentioning

confidence: 99%