Left Atrial Thrombus Associated With Interatrial Septal Occluder 5 Years After Implantation

Very Late Amplatzer Device Thrombosis and Stroke

“…Belgrave and Cardozo 8 reported the case of a 46-year-old woman who presented with ischemic stroke 5 years after the implantation of an Amplatzer device, in which a left-sided thrombus was identified; in that case, a prothrombotic state was ruled out. Misra et al 9 reported a case with late (5 years) thrombosis of a StarFLEX device in a 74-year-old patient, although it was suspected that a nickel allergy could have contributed to the onset of this complication. With regard to treatment, the first option is anticoagulation, which in most cases leads to thrombus resolution.…”

Paradoxes in embolism: management of a young female patient with atrial septal defect after acute myocardial infarction

“…не стоит забывать об описанных случаях ранних (реже -отсроченных) тромбозов окклюдера [21]. при ретроспективном 6-тимесячном анализе данных 1000 пациентов, перенёсших чрескожное закрытие открытого овального отверстия и дмпп, частота тромбозов во втором случае составила 1,2%.…”

Very late (>5 years) thrombus formation on an atrial septal defect device: a case report

“…Although only few cases of late thrombosis (>1 year) of ASD devices have been reported, it need prevention to prove long-term safety of these devices. 2,3,[5][6][7][8][9][10] In a study involving 407 patients with ASD which were closed using different occluders, Krumsdorf et al found amplatzer septal occluder as less thrombogenic than other device. 11 In a systemic review which included 17 case reports, thrombosis was reported in all currently used devices, but showed lower incidence with new generation devices such as amplatzer septal occluder.…”

“…9 Similarly, Satish et al also reported a case of left trail thrombus formation in 74 year old woman after 5 years of Star Flex atrial septal occluder device implantation. 10,11 The cause of late thrombosis after ASD device closure is not known but the antiplatelet regimen might play a crucial role. No guidelines or randomized controlled trials clearly suggest a particular duration of antiplatelet or antithrombotic therapy following transcatheter closure of ASD.…”

“…However, the very long-term safety of these devices is still a question that needs answer. Although only few cases of late thrombosis (>1 year) of ASD devices have been reported, it need prevention to prove long-term safety of these devices 2,3,[5][6][7][8][9][10].…”