Left heart function in COPD

Struß, Nadja; Bauersachs, Johann; Welte, Tobias; Hohlfeld, Jens M.

doi:10.1007/s00059-019-4816-5

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…In response to increased afterload these factors may influence right ventricular function. 29,30 Furthermore, there was a positive coherence between pPTT Q-S and RV S´in COPD patients. pPTT R-S and RV S´did not show a significant correlation but there was a trend towards significance.…”

Section: Discussionmentioning

confidence: 92%

Doppler‐derived pulmonary pulse transit time measurements in chronic obstructive pulmonary disease: Reproducibility and cardiopulmonary function

Löffler,

Westhoff‐Bleck,

Welte

et al. 2024

Echocardiography

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IntroductionDoppler‐derived pulmonary pulse transit time (pPTT) is an auspicious hemodynamic marker in chronic pulmonary diseases. The aim is to compare four distinct pPTT measurements and its relation to right cardiac and pulmonary function.MethodsProspectively, 25 chronic obstructive pulmonary disease (COPD) patients (four patients excluded) and 32 healthy subjects underwent repeated distinct pPTT measurements, standard echocardiography, and pulmonary function testing on the same day. pPTT was defined as the interval from the R or Q‐wave in the electrocardiogram to the corresponding pulse wave Doppler peak late systolic (S) 2 or diastolic (D) pulmonary vein flow velocity (pPTT R‐S, Q‐S, R‐D, Q‐D). Reproducibility was assessed using Bland–Altman analysis, coefficient of variation (COV), intraclass correlation coefficient (ICC), and power calculations. Associations with right ventricular RV tissue and pulse wave Doppler velocities (RV E', RV S', RV A', RV E, RV A, RV E/E', RV E/A), TAPSE, right ventricular fractional area change, left ventricular systolic and diastolic function (LV ejection fraction, E, A, E/A, E/E', septal E', lateral E'), LA diameters, as well as forced expiratory volume in 1 s, forced vital capacity (FVC) predicted (%), and in liters were analyzed.ResultsThere was no significant difference and no bias between pPTT measures (p range: .1–.9). COV was in COPD 1.2%–2.3%, in healthy subjects 1.0%–3.1%. ICC ranged from .92 (COPD) to .96 (healthy subjects). In COPD significant correlations were found for pPTT R‐S, Q‐S and R‐D with RV E`, (all > ρ: .49, < p = .0364), pPTT R‐S, Q‐S with RV E/E` (both > ρ: .49, < p = .0291), pPTT Q‐S with RV S´ (ρ: .58, p = .0134), RV A (ρ: .59, p = .0339) and heart rate > ρ: −.39, < p = .0297). pPTT R‐S, R‐D showed significant correlations with FVC predicted (%) (ρ: .48 p = .0224) and FVC (l) (ρ:.47 p = .0347).ConclusionsAll pPTT measures exhibited high reproducibility. In COPD patients pPTT measures correlate with diastolic right ventricular function. Defining Q as starting point seems clinically advantageous considering electromechanical desynchrony in patients with conduction disorders.

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Section: Discussionmentioning

confidence: 92%

Doppler‐derived pulmonary pulse transit time measurements in chronic obstructive pulmonary disease: Reproducibility and cardiopulmonary function

Löffler,

Westhoff‐Bleck,

Welte

et al. 2024

Echocardiography

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“…Furthermore, LVESV differs for men and women, 6 also in COPD patients 11 . Interestingly, in COPD patients without cardiac disease, LVEDV was found to increase following bronchodilator therapy 13 …”

Section: Lung Dysfunction and LV Sizementioning

confidence: 99%

“…11 Interestingly, in COPD patients without cardiac disease, LVEDV was found to increase following bronchodilator therapy. 13 F I G U R E 1 (A) The distribution of (group averaged) data points in the left ventricular volume domain for three GOLD classes (N = 13 for type 1, N = 12 for 2, and N = 17 for 3), their mean value, as well as for the controls (N = 30). End-systolic volume (ESV) is plotted against end-diastolic volume (EDV).…”

Section: Lung Dysfunction and LV Sizementioning

confidence: 99%

“…Interestingly, EF was consistently reported not to be a successful participant in the race for detecting COPD-related changes in LV performance. 5,[9][10][11][12][13] The finding of an unaffected EF is generally interpreted as "preserved" LV function. However, as Figure 1B demonstrates, EF cannot be a realistic candidate in view of the documented same-direction changes of ESV and EDV when considering various GOLD stages.…”

Section: Lung Dysfunction and LV Sizementioning

confidence: 99%

“…That is strange. Interestingly, EF was consistently reported not to be a successful participant in the race for detecting COPD‐related changes in LV performance 5,9–13 . The finding of an unaffected EF is generally interpreted as “preserved” LV function.…”

Section: What To Measure After the Silent Phase Of Copd?mentioning

confidence: 99%

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