Left Hemisphere Lateralization of Epileptic Focus Can Be More Frequent in Temporal Lobe Epilepsy Surgical Patients with No Consensus Associated with Depression Lateralization

Radaelli, Graciane; Majolo, Fernanda; Leal-Conceição, Eduardo; Santos, Francisco de Souza; Escobar, Vinícius Spencer; Zanirati, Gabriele; Portuguez, Mirna Wetters; Scorza, Fúlvio A.; Costa, Jaderson Costa da

doi:10.1159/000513537

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…It is common for lateralized epileptiform activity to originate in the left temporal lobe. 84 Although the majority of clinical sEEG electrodes are placed in the left hemisphere this does not explain our hemispheric differences findings as our proportion analysis accounts for uneven contact numbers in each hemisphere.…”

Section: Discussionmentioning

confidence: 81%

More widespread and rigid neuronal representation of reward expectation underlies impulsive choices

Cowan,

Davis,

Kundu

et al. 2024

Preprint

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Impulsive choices prioritize smaller, more immediate rewards over larger, delayed, or potentially uncertain rewards. Impulsive choices are a critical aspect of substance use disorders and maladaptive decision-making across the lifespan. Here, we sought to understand the neuronal underpinnings of expected reward and risk estimation on a trial-by-trial basis during impulsive choices. To do so, we acquired electrical recordings from the human brain while participants carried out a risky decision-making task designed to measure choice impulsivity. Behaviorally, we found a reward-accuracy tradeoff, whereby more impulsive choosers were more accurate at the task, opting for a more immediate reward while compromising overall task performance. We then examined how neuronal populations across frontal, temporal, and limbic brain regions parametrically encoded reinforcement learning model variables, namely reward and risk expectation and surprise, across trials. We found more widespread representations of reward value expectation and prediction error in more impulsive choosers, whereas less impulsive choosers preferentially represented risk expectation. A regional analysis of reward and risk encoding highlighted the anterior cingulate cortex for value expectation, the anterior insula for risk expectation and surprise, and distinct regional encoding between impulsivity groups. Beyond describing trial-by-trial population neuronal representations of reward and risk variables, these results suggest impaired inhibitory control and model-free learning underpinnings of impulsive choice. These findings shed light on neural processes underlying reinforced learning and decision-making in uncertain environments and how these processes may function in psychiatric disorders.

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Section: Discussionmentioning

confidence: 81%

More widespread and rigid neuronal representation of reward expectation underlies impulsive choices

Cowan,

Davis,

Kundu

et al. 2024

Preprint

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“…15 Both antisocial personality disorder and depression are alleviated in patients who have undergone resective epilepsy surgery. 17,19 Based on the literature, it can be stated that epilepsy is not only a neurological problem but also a social issue. Therefore, studies on epilepsy pathogenesis and new strategies for epilepsy prevention and treatment are vital.…”

Section: Introductionmentioning

confidence: 99%

Taxifolin as a novel therapeutic agent for epileptic seizures induced by caffeine-induced oxidative stress in rats

Yasar,

Altuner,

Bulut

et al. 2023

Adv Clin Exp Med

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Background. Epilepsy is a severe neurological disease that results from excessive and/or synchronized neuronal activity in the brain, and oxidative stress plays a role in its pathogenesis. Taxifolin is a flavonoid that exhibits antioxidant activity. Objectives.To investigate the effects of taxifolin on caffeine-induced epileptic seizures in rats and reveal the role of antioxidant activity in antiepileptic therapy. Materials and methods.Forty rats were divided into 4 groups (n = 6/group): caffeine 300 mg/kg group (CG), taxifolin 50 mg/kg + caffeine 300 mg/kg group (TCG), 2 mg/kg diazepam + 300 mg/kg caffeine group (DCG), and a healthy group (HG). Taxifolin was given to the TCG, and diazepam was given to the DCG orally. One hour later, caffeine was injected intraperitoneally into the CG, TCG and DCG rats. The time between the caffeine injection and the contractions (the latency period) was determined. Animals were euthanized 1 h after caffeine injection, and brain tissues were biochemically examined for oxidants and antioxidants.Results. Taxifolin and diazepam prolonged the latency period to a similar extent (p = 0.549), while taxifolin was more successful in preventing mortality. Taxifolin suppressed the caffeine-induced increase in myeloperoxidase, total oxidant status and oxidative stress index, and decreased total glutathione, superoxide dismutase and total antioxidant status more effectively than diazepam (p < 0.05). Conclusions.We showed the relationship between antioxidant activity and epilepsy treatment, and demonstrated that taxifolin may be useful for treating epilepsy.

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Targeting Endocannabinoid System in Epilepsy: For Good or for Bad

Martínez-Aguirre¹,

Çınar

Rocha³

2022

Neuroscience

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Left Hemisphere Lateralization of Epileptic Focus Can Be More Frequent in Temporal Lobe Epilepsy Surgical Patients with No Consensus Associated with Depression Lateralization

Cited by 3 publications

References 41 publications

More widespread and rigid neuronal representation of reward expectation underlies impulsive choices

More widespread and rigid neuronal representation of reward expectation underlies impulsive choices

Taxifolin as a novel therapeutic agent for epileptic seizures induced by caffeine-induced oxidative stress in rats

Targeting Endocannabinoid System in Epilepsy: For Good or for Bad

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