Left lateralized white matter microstructure accounts for individual differences in reading ability and disability

Niogi, Sumit N.; McCandliss, Bruce D.

doi:10.1016/j.neuropsychologia.2006.01.011

Cited by 253 publications

(267 citation statements)

References 53 publications

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“…These findings are in line with previous research that purports a similar relationship between white matter integrity and reading for both skilled and poor readers irrespective of prior childhood brain tumor (Niogi & McCandliss, 2006). The current study replicates IFOF findings from a recent study using a similar ROI method in adults, and adds the PT-OT as an important pathway particularly in brain tumor survivors (Vandermosten, et al, 2012).…”

Section: White Matter Integrity and Word Readingsupporting

confidence: 92%

Reading skill in adult survivors of childhood brain tumor: A theory-based neurocognitive model.

et al. 2014

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Objective: This study investigated the relationship between word reading and white matter (WM) integrity within a neuroanatomical-based reading system comparing adult survivors of childhood brain tumors and controls. It was predicted that the association between WM integrity and word reading would be mediated by processing speed, and this indirect effect would be moderated by group. Method: Thirty-seven adult survivors of childhood brain tumor and typically developing adults participated (age M = 24.19 ± 4.51 years, 62% female). DTI Tractography identified the WM tract for 3 of the reading system connections: inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), and parietotemporal-occipitotemporal connection (PT-OT). Results: Fractional anisotropy values (FA) of the PT-OT tract were significantly correlated with word reading in survivors and controls (r = .45, .58, respectively; p < .05) and IFOF values were associated with reading in survivors only (r = .59, p < .01). Further, the moderated mediated model was significant for PT-OT and IFOF, such that the indirect effect of processing speed was only present for survivors (CI: PT-OT: 2.90, 28.41, IFOF: 2.92, 40.17). Conclusion: Results suggest the tracts emerging from the occipitotemporal area are a critical component of the reading system in adults. The finding that processing speed was the mechanism by which WM was associated with reading in survivors is in alignment with the developmental cascade model. Current findings bolster the existing theory-based models of reading using innovative diffusion tensor imaging and moderated mediation statistical neurodevelopmental model, establishing the role of processing speed and specific WM pathway integrity in word reading skill.

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Section: White Matter Integrity and Word Readingsupporting

confidence: 92%

Reading skill in adult survivors of childhood brain tumor: A theory-based neurocognitive model.

et al. 2014

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“…However, we did find functional differences in the left inferior frontal gyrus, the left superior parietal lobule and the left occipitotemporal cortex. Furthermore, most studies using diffusion tensor imaging (Beaulieu et al, 2005;Deutsch et al, 2005;Klingberg et al, 2000;Niogi and McCandliss, 2006) and voxelbased morphometry (VBM) (Eckert et al, 2005;Silani et al, 2005) have associated dyslexia with changes in anatomical connections of temporo-parietal regions. To date, only one VBM study found reduced gray matter density in the left inferior occipitotemporal cortex in adults and adolescents with dyslexia (Kronbichler et al, 2008).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia

et al. 2011

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The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia van der Mark, S; Klaver, P; Bucher, K; Maurer, U; Schulz, E; Brem, S; Martin, E; Brandeis, D van der Mark, S; Klaver, P; Bucher, K; Maurer, U; Schulz, E; Brem, S; Martin, E; Brandeis, D (2011). The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia. The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia Abstract Developmental dyslexia is a severe reading disorder, which is characterized by dysfluent reading and impaired automaticity of visual word processing. Adults with dyslexia show functional deficits in several brain regions including the so-called "Visual Word Form Area" (VWFA), which is implicated in visual word processing and located within the larger left occipitotemporal VWF-System. The present study examines functional connections of the left occipitotemporal VWF-System with other major language areas in children with dyslexia. Functional connectivity MRI was used to assess connectivity of the VWF-System in 18 children with dyslexia and 24 age matched controls (age 9.7-12.5 years) using five neighbouring left occipitotemporal regions of interest (ROIs) during a continuous reading task requiring phonological and orthographic processing. First, the results revealed a focal origin of connectivity from the VWF-System, in that mainly the VWFA was functionally connected with typical left frontal and parietal language areas in control children. Adjacent posterior and anterior VWF-System ROIs did not show such connectivity, confirming the special role that the VWFA plays in word processing. Second, we detected a significant disruption of functional connectivity between the VWFA and left inferior frontal and left inferior parietal language areas in the children with dyslexia. The current findings add to our understanding of dyslexia by showing that functional disconnection of the left occipitotemporal system is limited to the small VWFA region crucial for automatic visual word processing, and emerges early during reading acquisition in children with dyslexia, along with deficits in orthographic and phonological processing of visual word forms. ÔØ Å ÒÙ× Ö ÔØThe left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the cont...

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“…A growing number of DWI studies in children have linked regional white matter microstructure to performance levels on, e.g., reading (Niogi and McCandliss, 2006), response inhibition (Madsen et al, 2010), and working memory (Vestergaard et al, 2011) tasks. In healthy young right-handed adults, faster right-relative to lefthanded responses have been correlated with higher FA in the left corticospinal tract in an auditory simple reaction time task (Bohr et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Brain microstructural correlates of visuospatial choice reaction time in children

et al. 2011

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The corticospinal tracts and the basal ganglia continue to develop during childhood and adolescence, and indices of their maturation can be obtained using diffusion-weighted imaging. Here we show that a simple measure of visuomotor function is correlated with diffusion parameters in the corticospinal tracts and neostriatum. In a cohort of 75 typically-developing children aged 7 to 13 years, mean 5-choice reaction times (RTs) were assessed. We hypothesised that children with faster choice RTs would show lower mean diffusivity (MD) in the corticospinal tracts and neostriatum and higher fractional anisotropy (FA) in the corticospinal tracts, after controlling for age, gender, and handedness. Mean MD and/or FA were extracted from the right and left corticospinal tracts, putamen, and caudate nuclei. As predicted, faster 5-choice RTs were associated with lower MD in the corticospinal tracts, putamen, and caudate. MD effects on RT were bilateral in the corticospinal tracts and putamen, whilst right caudate MD was more strongly related to performance than was left caudate MD. Our results suggest a link between motor performance variability in children and diffusivity in the motor system, which may be related to: individual differences in the phase of fibre tract and neostriatal maturation in children of similar age, individual differences in motor experience during childhood (i.e., use-dependent plasticity), and/or more stable individual differences in the architecture of the motor system.

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Left lateralized white matter microstructure accounts for individual differences in reading ability and disability

Cited by 253 publications

References 53 publications

Reading skill in adult survivors of childhood brain tumor: A theory-based neurocognitive model.

Reading skill in adult survivors of childhood brain tumor: A theory-based neurocognitive model.

The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia

Brain microstructural correlates of visuospatial choice reaction time in children

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