Left Lung Replantation with Immediate Right Pulmonary Artery Ligation

Alican, F; Cayirli, Mukadder; Isin, Erol; Hardy, James D.

doi:10.1097/00000658-197107010-00006

Cited by 14 publications

(1 citation statement)

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“…This view was subsequently proven to be incorrect with the reported fixed or high vascular resistance often being caused by artifacts at the arterial or venous anastomoses.5,19 If meticulous surgical techniques are employed, transplanted lungs can have normal pulmonary vascular resistance at rest and with the approximate doubling of pulmonary artery blood flow that occurs with contralateral pulmonary artery ligation or occlusion. 1,17,19,21,22 However, the vascular response of transplanted lungs to very large increases in pulmonary blood flow remains to be elucidated. The data reported by Ebert and Hudson 10 suggests that the pulmonary vascular resistance of transplanted lungs is not normal at the increased blood flows associated with treadmill exercise.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary and Hemodynamic Function in Dogs During Exercise: Effects of Lung Autotransplantation

Montefusco

Feinstein²,

Rao³

et al. 1983

Angiology

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An airtight facemask/mouthpiece assembly has been devised to facilitate the performance of a wide range of pulmonary function tests during treadmill exercise in dogs. Using this appliance, data were obtained from 6 normal dogs and 3 of the same dogs after left lung autotransplantation. All measurements were made during awake, resting conditions and again after 5-7 minutes of moderate exercise. Resting values for pulmonary function tests, hemodynamic parameters, blood gases and pH from both pulmonary and systemic arterial blood samples did not differ significantly between normal dogs and those studied after left lung autotransplantation. During treadmill exercise, cardiac output doubled and pulmonary vascular resistance decreased comparably in both groups of dogs. Heart rates in both groups rose to approximately 22 b/min and blood gases and pH remained normal. These results indicate the facemask/mouthpiece assembly permits normal ventilation during treadmill exercise. In addition, these data support the view that pulmonary autotransplantation per se need not impose obligatory defects in ventilatory and hemodynamic function despite the increased demands of treadmill exercise.

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Section: Discussionmentioning

confidence: 99%