Left-Sided Excess in the Laterality of Cutaneous Melanoma

Brewster, David H.; Vries, Esther de

doi:10.1001/archderm.144.9.1235-a

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…This suggests that a site-specific effect of sun exposure might be occurring in males but not in females, perhaps because of sex-related differences in occupational exposure or use of sun protection. Our results showed a higher count of melanomas on the left arm compared with the right arm, which is consistent with other studies that have shown a left-sided excess of melanomas [29–31]. It has been suggested that this could be because of an asymmetric distribution of melanocytes or greater sun exposure to the left side [29–31].…”

Section: Discussionsupporting

confidence: 92%

The anatomic distribution of melanoma and relationships with childhood nevus distribution in Colorado

Juhl¹,

Byers

Robinson³

et al. 2009

Melanoma Research

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The nature of the relationship between nevus development in childhood and later development of melanoma is unclear. Data on melanoma diagnoses by histologic type and anatomic site were obtained for 2351 white, non-Hispanics in Colorado from the Colorado Central Cancer Registry between 2000 and 2004. Nevus size and body site were ascertained during skin exams conducted in the summer of 2007 on 717 white, non-Hispanic children aged 8-9 years. Chi-square goodnessof-fit analysis was used to assess the association between the anatomic site distributions of nevi versus melanoma. Superficial spreading melanoma was the most frequent histology, followed by lentigo maligna melanoma. Nodular melanoma was the least common histology. For males, there was no significant difference between the distribution of medium-sized (≥2mm) nevi and the distribution of both superficial spreading and nodular melanomas. For females, there was no significant difference between the anatomic distribution of small-sized (< 2mm) nevi and the distribution of nodular melanoma, and there was marginal evidence for a difference between the distribution of medium-sized (≥2mm) nevi and the distribution of nodular melanoma. There was evidence for a difference between all of the nevus distributions and the distributions of superficial spreading and lentigo maligna melanoma in females. The similarities between the nevus and melanoma distributions are interesting findings, but it is difficult to interpret the significance of these findings based on the current state of knowledge of melanoma etiology.

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Section: Discussionsupporting

confidence: 92%

The anatomic distribution of melanoma and relationships with childhood nevus distribution in Colorado

Juhl¹,

Byers

Robinson³

et al. 2009

Melanoma Research

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show abstract

“…In a retrospective American study of 1047 skin cancers, a significant left‐side excess of skin cancers was observed in men, but not in women . Although some studies found a slight left‐side excess of melanomas (with a left/right ratio of 1·10:1·15) irrespective of sex and anatomical location, suggesting that other mechanisms could play a role in such an asymmetrical distribution, the major difference between sexes in the left/right ratio of peripheral head and neck melanomas, combined with the absence of any difference in other parts of the body in our study, strongly supports a major role of sun exposure in cars in melanocarcinogenesis …”

Section: Discussioncontrasting

confidence: 64%

“…More precise locations have not generally been recorded. Furthermore, differences in laterality (right vs. left) between the sexes have rarely been analysed . Our hypothesis was that many differences according to sex could exist, some of which may not have been described extensively to date.…”

mentioning

confidence: 99%

Comparison of anatomical locations of cutaneous melanoma in men and women: a population‐based study inFrance

et al. 2014

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“…They hypothesized that this could be partly because of UV exposure while driving. However, this explanation was considered unsatisfactory because of similar asymmetry at body sites that are not really exposed to UV in cars (Bulliard et al, 2008) and similar findings in countries where the driver's seat is on the right (Australia, England, and Scotland) (Brewster and de Vries, 2008;Bulliard et al, 2008). Apart from chance or confusion in codes for left and right, other hypotheses were a differential side migration of melanocytes from the neural crest to the skin during embryogenesis, and an asymmetry in the circulatory system resulting in differential angiogenesis and response to DNA damage.…”

Section: Discussionmentioning

confidence: 99%

Sex-Related Location of Head and Neck Melanoma Strongly Argues for a Major Role of Sun Exposure in Cars and Photoprotection by Hair

Lesage

Barbe

Clainche

et al. 2013

Journal of Investigative Dermatology

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Head and neck melanomas (HNMs) are frequent and have a poorer prognosis than melanomas at other sites. Photoprotection in these locations is difficult. In this population-based study of 279 HNMs diagnosed in a French region between 2004 and 2009, major differences were found between genders. A clearcut, sex-related distribution was found between a "peripheral" area (scalp, forehead, temples, ears, and neck) and a "central" one (other parts of the face), with 56.7% of HNMs being located in the peripheral area in men and 79.3% in the central area in women (P<0.0001). Moreover, HNMs located in the peripheral area occurred on the left side in 57.6% of men and on the right side in 73.1% of women (P=0.009). Peripheral HNMs differed from central HNMs by a higher proportion of invasive tumors, nodular or superficial spreading melanomas, and a lower proportion of lentigo maligna melanomas (LMMs). We hypothesized that this differential distribution between men and women could be explained mostly by a major role of long-term photoprotection by hair and sun exposure in a car. Important public health messages could result from these observations, such as the role of hairstyles in melanoma prevention and the importance of reducing sun exposure in a car, particularly in professional drivers.

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Left-Sided Excess in the Laterality of Cutaneous Melanoma

Cited by 9 publications

References 4 publications

The anatomic distribution of melanoma and relationships with childhood nevus distribution in Colorado

The anatomic distribution of melanoma and relationships with childhood nevus distribution in Colorado

Comparison of anatomical locations of cutaneous melanoma in men and women: a population‐based study inFrance

Sex-Related Location of Head and Neck Melanoma Strongly Argues for a Major Role of Sun Exposure in Cars and Photoprotection by Hair

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