A 65-year-old man was admitted to the hospital because of Hodgkin's disease of the anterior mediastinum and the radiographic finding of a pelvic mass.The patient had been well until about four months earlier, when pleuritic pain developed in the left side of the chest and he entered another hospital. Radiographs of the chest, a ventilation-perfusion scan, and the results of a pulmonary angiographic examination were reported to be normal, and the patient was discharged after three days with a diagnosis of "viral pleurisy." At follow-up examination performed by his personal physician two months later because of left scapular pain, radiographs of the chest (Fig. 1) showed a large anterior mediastinal mass. A computed tomographic (CT) scan of the chest (Fig. 2) revealed a lobulated heterogeneous mass measuring 6 cm in the anterior mediastinum and several enlarged mediastinal lymph nodes. A CT scan of the abdomen (Fig. 3) and pelvis showed evidence of a splenectomy, left nephrectomy, and cholecystectomy. A mass, 4 cm in diameter, abutted the sigmoid colon; another mass, 2.5 cm in diameter, was anterolateral to the descending colon at the level of L1, and a nodule, 1 cm in diameter, was posterior to the descending colon at the level of T12. No retroperitoneal, iliac, or inguinal lymphadenopathy was seen. A CTguided needle-biopsy examination of the anterior mediastinal mass was not diagnostic. Twenty-five days before the admission under discussion, the patient was admitted to this hospital.The patient was a sedentary professional with no known exposure to occupational hazards. He had undergone a splenectomy and left nephrectomy 33 years earlier, after trauma to the abdomen. He first came to this hospital six years before admission because of pneumococcal sepsis, was treated successfully, and re-ceived pneumococcal vaccine. A cholecystectomy was performed elsewhere six months before admission. The patient had been fatigued for eight months and had recently lost an uncertain amount of weight on a low-calorie diet.He did not smoke, drank alcohol sparingly, and took no medications; he reported no fever, chills, sweats, dyspnea, cough, hemoptysis, or bladder or bowel symptoms. Physical examination was negative; no lymphadenopathy or hepatomegaly was found.The hematocrit, white-cell count, and prothrombin and partial-thromboplastin times were normal, as were the values for urea nitrogen,