Left Ventricular Chamber Volume, Mass, and Function in Severe Coronary Artery Disease

Abstract

Twenty-three patients, 15 of whom had clinical and electrocardiographic evidence of previous myocardial infarction, were studied by coronary arteriography and biplane angiocardiography. End-diastolic volume ranged from 55 to 317 ml/m 2 , left ventricular mass from 83 to 294 g/m 2 and ejection fraction from 0.13 to 0.75. An increased enddiastolic volume was associated with an increased left ventricular mass (r = 0.77, P < 0.01). In 15 of the 23 patients mitral regurgitant volume ranged from 0.7 to 4.7 L/min/m 2 and an end-diastolic volume greater than 154 ml/m 2 was associated with mitral regurgitation. The ejection fraction was significantly reduced in the absence as well as the presence of mitral regurgitation. These observations on coronary artery disease in 23 patients with refractory angina pectoris or persistent congestive heart failure, or both, reveal that in this group of patients (1) a dilated left ventricle was hypertrophied and the extent of hypertrophy was proportional to the dilatation; (2) an enlarged left ventricle was frequently associated with mitral regurgitation; and (3) dilatation, hypertrophy, and mitral regurgitation were interpreted as manifestations of reduced left ventricular performance.

Effects of buccal nitrate on left ventricular haemodynamics and volume at rest and during exercise‐induced angina.

“…Further errors may result both from attenuation of counts from regions of the left ventricle most distant from the probe during ventricular dilatation, as well as from changes in background counts during exercise. Moreover the left ventricular volumes cal-culated at rest and during dynamic exercise in the present series were similar to those derived by conventional gamma camera and biplane cineangiography techniques in patients with equivalent coronary artery disease (Rackley et al, 1970;Feild etal., 1972;Links etal., 1982;McKay etal., 1984). An increased pulmonary blood flow during exercise would be expected to increase background activity; indeed Okada et al (1980) have demonstrated that lung activity increases as left ventricular filling pressure rises.…”

A rest and exercise haemodynamic evaluation of a new cardio‐selective beta‐adrenoceptor blocker celiprolol alone and in combination with nitroglycerine in ischaemic heart disease.

“…Since ejection fraction is the ratio of stroke volume to end-diastolic volume, left ventricular end-diastolic volume index can be derived from simultaneously measured stroke volume index and ejection fraction. It appears that the left ventricular volume calculated at rest and during dynamic exercise in the present series were similar to those derived by conventional gammacamera and biplane cineangiography techniques in patients with equivalent coronary artery disease (Links et al, 1982;Rackley et al, 1970;Feild et al, 1972;McKay et al, 1984).…”

Severe aortic stenosis without left ventricular hypertrophy: prevalence, predictors, and short-term follow up after aortic valve replacement.

“…Subgroup analysis ofpatients without LVH according to mass criteria Among patients without LVH 12/21 (57%) showed LV concentric remodelling (LVCR) (relative wall thickness > 0A45) and 9/21 (43%) did not. Patients without LVCR were younger than those with LVH and those with LVCR (52 (23) v 65 (14) and 64 (19) years, respectively, P < 0 05). The interval since diagnosis of aortic stenosis was 3-2 (6 2) years in patients without LVCR and 8&2 (6-1) years in patients with LVCR (P < 0-05).…”