Left ventricular diastolic dysfunction in patients with ST-elevation myocardial infarction following early and late reperfusion by coronary intervention

Chen, Xianghui; Liu, Fucheng; Xu, Hao; Zha, Daogang; Xiu, Jiancheng; Guo, Jun; Zhang, Aidong

doi:10.1016/j.ijcard.2016.11.146

Cited by 13 publications

(10 citation statements)

References 19 publications

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“…Interestingly, Nøjgaard et al made mention of no correlation between serum YKL-40 and ejection fraction and other echocardiographic indices of systolic or diastolic heart function during follow-up in patients with AMI [ 12 ]. Log BNP after one month was associated with both systolic and diastolic functions in accordance with previous studies [ 25 , 26 ] and log YKL-40 at the first month. Hedegaard et al also concluded plasma YKL-40 may be an indirect marker of LV ejection fraction recovery, independent of hs-CRP, and higher plasma YKL-40 was related with lower recovery.…”

Section: Discussionsupporting

confidence: 91%

“…To our knowledge, this is the first report demonstrating a relationship plasma YKL-40 and diastolic dysfunction. Chen et al showed that left ventricle diastolic dysfunction was observed in most of AMI patients even after successful invasive treatment [ 26 ]. Yoon et al described that age, increased NT-proBNP, and impaired diastolic recovery were independent predictors of major adverse cardiovascular events in 463 patients with preserved LV systolic function at 6 months after AMI [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction

Pala

Sari

Kahveci

et al. 2018

Cardiology Research and Practice

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Objective The aim of the study was to determine an association between the plasma YKL-40 level and echocardiographic left ventricle systolic and diastolic function parameters in patients with acute myocardial infarction. Subjects and Methods The study included 46 patients with acute myocardial infarction. Serum brain natriuretic protein (BNP) and YKL-40 levels were analyzed on admission and after one month. Left ventricle systolic and diastolic functions and Tei index were computed by transthoracic echocardiography. Results Plasma YKL-40 was significantly higher in patients with acute myocardial infarction (AMI) (101.7 μg/L versus 34 μg/L, resp., p < 0.001) and remained higher than in healthy subjects after one month. The levels of YKL-40 on admission were correlated with log BNP on admission (r=0.41, p=0.004), Tei index (r=0.44, p=0.002), left atrium volume index (r=0.32, p=0.02), and mitral septal annular E/e′ (r=0.44, p=0.003). Death was more frequently observed in patients with plasma YKL-40 above the median value than in those with plasma YKL-40 below the median value (p=0.001; OR = 13.6 (2.5–72.3)). Conclusion YKL-40 elevations in patients with AMI remain at least one month and are associated with serum BNP elevations, diastolic dysfunction, and long-term increased overall mortality. It has prognostic importance in patients with AMI.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction

Pala

Sari

Kahveci

et al. 2018

Cardiology Research and Practice

View full text Add to dashboard Cite

show abstract

“…Data from the acute phase provided valuable information about these patients. For instance, Chen et al found diastolic dysfunction even after early reperfusion ( 12 ). Barberato et al also defined the E/E’ ratio as a predictor of LV remodeling following AMI ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…Ohlow et al reported that the incidence of ventricular arrhythmias was 4.7% in a German facility following STEMI ( 11 ). In addition to being arrhythmogenic, fibrotic areas are devoid of contractile properties, thus, resulting in increased wall stress and LV end-diastolic pressure, impaired relaxation, and ultimately, cavity dilatation and loss of contractile capacity ( 12 ). Clinically, such processes are considered to be diastolic and systolic dysfunctions.…”

Section: Introductionmentioning

confidence: 99%

Clinical and echocardiographic predictors of left ventricular remodeling following anterior acute myocardial infarction

Silveira¹,

Malagutte²,

Nogueira³

et al. 2021

Clinics

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OBJECTIVES: Coronary artery disease is the primary cause of death and is responsible for a high number of hospitalizations worldwide. Ventricular remodeling is associated with worse prognosis following ST-segment elevation myocardial infarction (STEMI) and is a risk factor for ventricular dysfunction and heart failure. This study aimed to identify the predictors of ventricular remodeling following STEMI. Additionally, we evaluated the clinical, laboratory, and echocardiographic characteristics of patients with anterior wall STEMI who underwent primary percutaneous intervention in the acute phase and at 6 months after the infarction. METHODS: This prospective, observational, and longitudinal study included 50 patients with anterior wall STEMI who were admitted to the coronary care unit (CCU) of a tertiary hospital in Brazil between July 2017 and August 2018. During the CCU stay, patients were evaluated daily and underwent echocardiogram within the first three days following STEMI. After six months, the patients underwent clinical evaluation and echocardiogram according to the local protocol. RESULTS: Differences were noted between those who developed ventricular remodeling and those who did not in the mean±standard deviation levels of creatine phosphokinase MB isoenzyme (CKMB) peak (no remodeling group: 323.7±228.2 U/L; remodeling group: 522.4±201.6 U/L; p =0.008) and the median and interquartile range of E/E’ ratio (no remodeling group: 9.20 [8.50-11.25] and remodeling group: 12.60 [10.74-14.40]; p =0.004). This difference was also observed in multivariate logistic regression. CONCLUSIONS: Diastolic dysfunction and CKMB peak in the acute phase of STEMI can be predictors of ventricular remodeling following STEMI.

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“…Guidelines recommend transthoracic echocardiography before discharge after STEMI to assess for infarct size and resting LV function, identifying patients at high risk for worse outcome [5]. In addition, it provides important information about diastolic function in the acute phase [6]. However, there are significant limitations due to often inaccurate discrimination of the endocardial border [7, 8] and the exam can be particularly cumbersome in acute cardiac disease due to arrhythmia, stress or hypercontractility of adjacent segments [9].…”

Section: Introductionmentioning

confidence: 99%

Baseline LV ejection fraction by cardiac magnetic resonance and 2D echocardiography after ST-elevation myocardial infarction – influence of infarct location and prognostic impact

et al. 2019

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Objectives The comparability of left ventricular ejection fraction (LVEF) measurements by cardiac magnetic resonance (CMR) and 2D echocardiography (2DE) early after ST-elevation myocardial infarction (STEMI) remains unclear. Methods In this study, LVEF measured by CMR and 2DE (Simpson's method) were compared in 221 patients after STEMI treated by primary percutaneous coronary intervention. 2DE image quality was systematically assessed and studies reported by an accredited examiner. Intermodality agreement was assessed by the Bland-Altman method. Major adverse cardiac events (MACE) were defined as the composite of death, myocardial infarction or hospitalisation for heart failure. Patients were followed up for a median of 40.9 months (IQR 28.1-56). Results After non-anterior STEMI, LVEF measurements by 2DE (single and biplane) were consistently underestimated in comparison to CMR (CMR 55.7 ± 9.5% vs. 2DE-4CV 49 ± 8.2% (p = 0.06), 2DE-2CV 52 ± 8% (p < 0.001), 2DE-biplane 53.5 ± 7.1% (p = 0.01)). After anterior STEMI, there was no significant difference in LVEF measurements by 2DE and CMR with acceptable limits of agreement (CMR 49 ± 11% vs. 2DE-4CV 49 ± 8.2% (p = 0.8), 2DE-2CV 49 ± 9.2% (p = 0.9), 2DEbiplane 49.6 ± 8% (p = 0.5)). In total, 15% of patients experienced a MACE during follow-up. In multivariate Cox regression analysis, reduced LVEF (< 52%) as assessed by either 2DE or CMR was predictive of MACE (2DE HR = 2.57 (95% CI 1.1-6.2), p = 0.036; CMR HR = 2.51 (95% CI 1.1-5.7), p = 0.028).Conclusions At baseline after non-anterior STEMI, 2D echocardiography significantly underestimated LVEF in comparison to CMR, whereas after anterior infarction, measurements were within acceptable limits of agreement. Both imaging modalities offered similar prognostic values when a reduced LVEF < 52% was applied. Key Points • After non-anterior STEMI, 2D-echocardiography significantly underestimated LVEF compared with cardiac MRI • An ejection fraction of < 52% in the acute post-infarct period by both 2D echocardiography and CMR offered similar prognostic values Keywords Anterior wall myocardial infarction . Magnetic resonance imaging . Cine . Echocardiography . ST-elevation myocardial infarction Abbreviation 2CV Two-chamber view 2DE 2D echocardiography 4CV Four-chamber view CMR Cardiac magnetic resonance DENSE Displacement encoding with stimulated echoes HR Hazard ratio IQR Interquartile range LGE Late gadolinium enhancement LVEF Left ventricular ejection fraction

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Left ventricular diastolic dysfunction in patients with ST-elevation myocardial infarction following early and late reperfusion by coronary intervention

Cited by 13 publications

References 19 publications

Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction

Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction

Clinical and echocardiographic predictors of left ventricular remodeling following anterior acute myocardial infarction

Baseline LV ejection fraction by cardiac magnetic resonance and 2D echocardiography after ST-elevation myocardial infarction – influence of infarct location and prognostic impact

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