Left Ventricular Diastolic Dysfunction in Diabetes Mellitus Type 2: PP.17.147

Exiara, Triada; Konstantis, Apostolos; Papazoglou, LP; Kouroupi, Maria; Kalpaka, Anastasia; Mporgi, L.; Risggits, Ali; Filippidou, Elissavet-Christina; Terzi, Sait; Papanastasiou, S

doi:10.1097/01.hjh.0000379073.02051.d5

Cited by 8 publications

(9 citation statements)

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“…Exiara et al . [ 14 ] in their study of 114 subjects stated that the prevalence of LV diastolic dysfunction in normotensive, asymptomatic and well-controlled DM type 2 patients is high, and increases with age. A total of 63.2% patients had diastolic dysfunction in their study compared to our prevalence of 54.33%.…”

Section: Discussionmentioning

confidence: 99%

Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function

Patil¹,

Patil²,

Shah³

et al. 2011

Journal of Cardiovascular Disease Research

144

101

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Background:The incidence of heart failure in diabetic subjects is high even in the absence of hypertension and coronary artery disease.Aims:The purpose of this study was to study the incidence of diastolic dysfunction in diabetic subjects and its relation to age, duration of diabetes mellitus (DM), Glycosylated hemoglobin (HbA1c) levels, obesity indices and diabetic microangiopathies.Settings and Design:This was a case control prospective study conducted at the teaching hospital during a one year period.Materials and Methods:A total of 127 subjects (case) with type 2 diabetes of more than five years duration were studied. Total 100 healthy subjects were included as the control group. Echocardiography was performed to assess left ventricular diastolic function.Results:Out of the total 127 subjects, 69 (54.33%) from the case group had diastolic dysfunction, and 11% amongst 100 in the control group population showed the diastolic dysfunction (P < 0.001). Patients with a longer duration of DM (of 11 to 15 years) had a higher prevalence of diastolic dysfunction (P < 0.02). Subjects with high waist circumference and high waist to hip ratio had statistically significant diastolic dysfunction with ‘P’ =0.001 and ‘P’ = < 0.02 respectively. Subjects with HbA1c > 7.5% had a higher prevalence of diastolic dysfunction than subjects with HbA1c < 7.5% (P < 0.02). Diastolic dysfunction was present in majority of the subjects with autonomic neuropathy and retinopathy.Conclusions:Present study reveals high incidence of diastolic dysfunction in asymptomatic diabetic; subjects and, this finding was correlated with the duration of diabetes, HbA1c levels, obesity indices and diabetic microangiopathies. We conclude that early diagnosis and institution of treatment will reduce morbidity and improve the outcomes, and prevent future heart failure.

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Section: Discussionmentioning

confidence: 99%

Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function

Patil¹,

Patil²,

Shah³

et al. 2011

Journal of Cardiovascular Disease Research

144

101

View full text Add to dashboard Cite

show abstract

“…Xiara et al [42] reported in their study that 63.2% of diabetic patients had LV diastolic dysfunction, 77.4% of them had impaired relaxation pattern, 22.6% had pseudonormal pattern and no one had restrictive pattern of diastolic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Early Detection of Diastolic Dysfunction in Diabetic Patients (Single Center Cross Sectional Study)

Ashour¹

2018

J Heart Cardiovasc Res

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“…In T2DM patients, the prevalence of diastolic dysfunction varies from 47% to 71% because of different echocardiographic criteria used for screening, patients’ cardiac function, and different diastolic dysfunction grades [ 19 , 20 , 21 , 22 ]. Similar to other studies, in our research 73% of patients had diastolic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with the Remission of Type 1 Diastolic Dysfunction after Dapagliflozin Treatment in Patients with Type 2 Diabetes

Braha

Albai

Timar

et al. 2020

JCM

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Patients with type 2 diabetes (T2DM) are at high risk of developing cardiovascular disease and heart failure (HF), both with preserved and reduced ejection fraction of the left ventricle. Previous research demonstrated that dapagliflozin treatment is associated with the remission of type 1 diastolic dysfunction (DD1) in patients with T2DM. The main aim of this study was to evaluate the possible baseline predictors associated with the remission of DD1 in patients with T2D after one year of dapagliflozin treatment. In this prospective and observational study, 45 patients with T2DM were evaluated before and after one year of treatment with 10 mg dapagliflozin daily added to their background therapy. In the studied group, 73.3% (33/45) of the patients had DD1 at baseline. The primary outcome of this research was DD1 remission. DD1 remission was associated with improvement of liver stiffness, an increase in estimated glomerular filtration rate (eGFR), and a decrease in hemoglobin A1c (HbA1c). Independent predictors for the remission of DD1 were a more than 0.4 kPa difference in the initial stiffness score and the 1-year assessment fibrosis score and a duration of diabetes ≤8 years. Age, body mass index (BMI), or patient weight after one year did not influence the DD1 outcome. Patients with a T2DM duration of less than eight years have the additional benefit of DD1 remission associated with dapagliflozin treatment beyond the conventional benefits such as improvements in glycemic control, cardiovascular, renal, and hepatic risk reductions. In patients with T2DM, the remission of DD1 was associated with decrease of liver stiffness.

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Left Ventricular Diastolic Dysfunction in Diabetes Mellitus Type 2: PP.17.147

Cited by 8 publications

References 0 publications

Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function

Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function

Early Detection of Diastolic Dysfunction in Diabetic Patients (Single Center Cross Sectional Study)

Factors Associated with the Remission of Type 1 Diastolic Dysfunction after Dapagliflozin Treatment in Patients with Type 2 Diabetes

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