Left ventricular diastolic dysfunction in normotensive diabetic patients in various age strata

Masugata, Hisashi; Senda, Shoichi; Goda, Fuminori; Yoshihara, Yumiko; Yoshikawa, K; Fujita, Norihiro; Daikuhara, Hiroyuki; Okuyama, Hiroomi; Taoka, Teruhisa; Kohno, Masakazu

doi:10.1016/j.diabres.2007.08.006

Cited by 24 publications

(22 citation statements)

References 31 publications

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“…Likewise, previous studies have shown that more than 40-75% of normotensive diabetic patients under excellent glycemic control had diastolic dysfunction [1,2,21]. In our study, the parameters of diastolic function were not different in the patients with DM2 and hypertension compared with the DM2 patients without hypertension.…”

Section: Differences In Left Ventricular Diastolic Measuressupporting

confidence: 53%

Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus and the Association With Coronary Artery Calcium Score: A Cardiac MRI Study

Graça¹,

Donato²,

Ferreira³

et al. 2014

American Journal of Roentgenology

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C a r d io p u l m o n a r y I m ag i ng • O r ig i n a l R e s e a rc hThis article is available for credit. This research was financially supported by Project "DoIT," which is cofinanced by the European Community Fund FEDER through COMPETE. rosis [10], which can be detected noninvasively by MDCT.Coronary artery disease is commonly cited as a mechanism underlying diastolic dysfunction [11]. Many of the same factors that contribute to atherosclerosis may also produce LV diastolic dysfunction by either direct mechanisms (e.g., hypertension and age-related vascular stiffening) or secondarily via coronary artery disease progression and resulting changes in myocardial compliance [11].There are limited and controversial published data on the relationship of CAC to LV diastolic function. Edvardsen et al. [12] reported that coronary atherosclerosis is associated with depressed regional LV systolic and diastolic wall strain measured by MRI tagging. Colletti et al. [13] found that a CAC score greater than 100 predicts an increased likelihood of clinically unsuspected LV regional wall motion abnormalities, which are C ardiovascular disease is the most frequent cause of death and disability in patients with type 2 diabetes mellitus (DM2). DM2 is responsible for diverse cardiovascular complications such as increased coronary atherosclerosis and left ventricular (LV) dysfunction. LV diastolic dysfunction is highly prevalent in DM2 [1,2], representing the earliest preclinical manifestation of LV dysfunction in patients with this condition [3][4][5][6].Over the past decade, cardiac MRI has been widely accepted as the reference standard for the assessment of cardiac structure and function because of its high spatial and temporal resolution, excellent image quality, and lack of geometric assumptions [7]. Cardiac MRI offers a variety of alternative approaches for evaluating diastolic function [8,9].The presence of coronary artery calcium (CAC) is indicative of coronary atheroscle-OBJECTIVE. The purpose of this study was to compare cardiac MRI-derived parameters of left ventricular (LV) diastolic function between uncomplicated type 2 diabetes mellitus (DM2) and normoglycemic control subjects and to evaluate whether these parameters of LV diastolic function are related to coronary atherosclerosis. SUBJECTS AND METHODS.We prospectively studied 41 subjects with DM2 and 21 normoglycemic control subjects (30 women and 32 men; mean age, 57.2 ± 7.1 [SD] years) with no evidence of overt cardiovascular disease. We used cardiac MRI to measure LV volumes, LV peak filling rate (PFR), and transmitral flow and CT to determine coronary artery calcium scores.RESULTS. Absolute values of the peak filling rate (PFR) were significantly lower in DM2 patients than in control subjects (mean ± SD, 293.2 ± 51.7 vs 375.7 ± 102.8 mL/s, respectively; p < 0.001). Mitral peak E velocities (mean ± SD, 42.8 ± 10.7 vs 48.8 ± 10.4 cm/s; p = 0.040) and peak E velocity-to-peak A velocity ratios (0.88 ± 0.3 vs 1.1 ± 0.3; p = 0.002) were also lower in DM2 patients com...

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Section: Differences In Left Ventricular Diastolic Measuressupporting

confidence: 53%

Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus and the Association With Coronary Artery Calcium Score: A Cardiac MRI Study

Graça¹,

Donato²,

Ferreira³

et al. 2014

American Journal of Roentgenology

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“…However, LV diastolic function and structure could be influenced by many factors, including aging, hypertension, and abnormal glucose tolerance. It has been suggested that aging is an important contributing factor affecting LV diastolic function [21,22]. In a study with normotensive diabetic subjects, LVDD was more apparent in the elderly than in the younger age group, and was correlated with the duration of diabetes [22].…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and insulin resistance are associated with abnormal left ventricular diastolic function and structure independent of blood pressure and fasting plasma glucose level

Hwang

Jee

Kang

et al. 2012

International Journal of Cardiology

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“…The classic echocardiographic and Doppler parameters have some limitations for the diagnosis of diastolic dysfunction because there is no clear and definitive diagnostic criterion [6][7][8][9][10][11][12][13][14][15][16][17]. Tissue Doppler imaging (TDI) is relatively a new technique and sensitive method that measures the velocity of the longitudinal motion (shortening and lengthening) of the mitral annulus and has an important role for early diagnosis of diastolic impairment in diabetic patients who may benefit from earlier treatment in order to prevent the progression to clinically overt heart failure [18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Early Detection of Diastolic Dysfunction in Diabetic Patients (Single Center Cross Sectional Study)

Ashour¹

2018

J Heart Cardiovasc Res

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Left ventricular diastolic dysfunction in normotensive diabetic patients in various age strata

Cited by 24 publications

References 31 publications

Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus and the Association With Coronary Artery Calcium Score: A Cardiac MRI Study

Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus and the Association With Coronary Artery Calcium Score: A Cardiac MRI Study

Metabolic syndrome and insulin resistance are associated with abnormal left ventricular diastolic function and structure independent of blood pressure and fasting plasma glucose level

Early Detection of Diastolic Dysfunction in Diabetic Patients (Single Center Cross Sectional Study)

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