Left ventricular diastolic function and cardiometabolic factors in obese normotensive children

Porcar-Almela, Manuel; Codoñer‐Franch, Pilar; Tuzón, MT; Navarro-Solera, María; Carrasco-Luna, Joaquín; Ferrando, Juan

doi:10.1016/j.numecd.2014.08.013

Cited by 23 publications

(22 citation statements)

References 28 publications

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“…In obesity, which is the main parameter of the metabolic syndrome, left and right ventricular dilatation and hypertrophy have been shown in previous studies. 15,16 The Bogalusa Heart Study revealed that obesity was associated with left ventricle dilatation and hypertrophy, and they also found that body mass index was the only independent predictor of left ventricle structure. 17 In our study, we found that left ventricle diameters, left ventricular mass, relative posterior wall thickness, and right ventricle free wall thickness were significantly higher in metabolic and non-metabolic syndrome obese groups compared with controls.…”

Section: Discussionmentioning

confidence: 99%

Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome

et al. 2019

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PurposeThe aim of our study was to assess left ventricle and right ventricle systolic and diastolic functions in obese adolescents with metabolic syndrome using conventional echocardiography and pulsed-wave tissue Doppler imaging and to investigate carotis intima-media thickness, and asymmetric dimethyl arginine levels.MethodsA total of 198 obese adolescents were enrolled in the study. The obese patients were divided into metabolic syndrome group and non-metabolic syndrome group. All subjects underwent laboratory blood tests, including asymmetric dimethyl arginine, complete two-dimensional, pulsed, and tissue Doppler echocardiography, and measurement of the carotid intima-media thickness.ResultsObese adolescents were characterised by enlarged left end-diastolic, end-systolic and left atrial diameters, thicker left and right ventricular walls compared with non-obese adolescents. The metabolic syndrome group had normal left ventricle systolic function, impaired diastolic function, and altered global systolic and diastolic myocardial performance. In the metabolic syndrome obese group patients, left ventricle mass was found positively correlated with body mass index, waist and hip circumferences, diastolic blood pressure, age, and waist-to-hip circumference ratio. The carotid intima-media thickness was found positively correlated with waist and hip circumferences and total cholesterol levels. Asymmetric dimethyl arginine levels were found positively correlated with systolic blood pressure, waist-to-hip circumference ratio, and diastolic blood pressure.ConclusionsThe results of this study demonstrate that metabolic syndrome in adolescence is associated with significant changes in myocardial geometry and function. In addition, it has been associated with a high level of asymmetric dimethyl arginine concentration and thicker carotid intima-media thickness reflecting endothelial dysfunction.

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Section: Discussionmentioning

confidence: 99%

Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome

et al. 2019

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“…Childhood obesity has been shown to be a cause of subclinical impairment of cardiac function in childhood. Left ventricular structural changes have been demonstrated in obese children and adolescents ( 2 ). Increased values for left ventricular mass index (LVMi) and carotid intima-media thickness (c-IMT) as well as abnormal results of Doppler imaging have been reported in childhood obesity ( 3 , 4 , 5 , 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents

Eklioğlu

Atabek²,

Akyürek³

et al. 2016

Jcrpe

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Objective:In this study, our aim was to determine cardiovascular risk and cardiac function in prediabetic obese children and adolescents.Methods:The study was conducted on 198 obese children and adolescents 6-18 years of age. Anthropometric measurements, blood pressure measurements, oral glucose tolerance test, lipid profile, and HbA1c levels of patients were assessed. Prediabetes was defined according to American Diabetes Association criteria. Left ventricular mass index (LVMi), carotid intima-media thickness (c-IMT), and tissue Doppler measurements records were used.Results:LVMi was found to be significantly higher in the prediabetes group (p=0.03). There were no statistically significant differences in right ventricular tissue Doppler measurements between the prediabetic and non-prediabetic groups. Left ventricular tissue Doppler measurements were significantly higher in the prediabetes group: LVEEM (left ventricular E/e ratio) (p=0.04); LVEM (left ventricular myocardial velocity cm/s) (p=0.035). LVMi was found to positively correlate with triglyceride level, diastolic blood pressure, waist circumference, body weight standard deviation score and to negatively correlate with high-density lipoprotein cholesterol (p=0.043, r=0.15; p=0.039, r=0.15; p=0.025, r=0.17; p=0.009, r=0.19; p=0.038, r=-0.15, respectively). LVEM was correlated with glucose (p=0.046, r=0.15) and LVEEM was correlated with systolic blood pressure (p=0.035, r=0.15). In linear regression analysis for clinical cardiovascular risk factors, fasting glucose level was the best predictor of LVEM.Conclusion:In this study, deterioration of cardiac function in prediabetic obese children and adolescents was shown. We recommend determining cardiovascular risk and cardiac dysfunction at early stages in prediabetic obese children and adolescents.

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“…The prevalence of obesity is rapidly spreading throughout the world with over 28% of adults having a body mass index (BMI) of ≥25 kg/m 2 [1,2] . In addition to the increased risk for type 2 diabetes, a growing number of studies have reported a high prevalence of cardiomyopathy in obese patients (∼40% by some estimates) [3] , with ‘preclinical’ myocardial damage [4] and diastolic dysfunction already evident in young adult (≤35 yrs) obese/diabetic patients [5] and even children [6] . Importantly, these cardiac derangements appear in the absence of detectable coronary disease or hypertension.…”

Section: Introductionmentioning

confidence: 99%

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

Katunga

Gudimella

Efird

et al. 2015

Molecular Metabolism

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ObjectiveLipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme that selectively neutralizes lipid hydroperoxides, and human gpx4 gene variants have been associated with obesity and cardiovascular disease in epidemiological studies. This study tested the hypothesis that LPPs underlie cardio-metabolic derangements in obesity using a high fat, high sucrose (HFHS) diet in gpx4 haploinsufficient mice (GPx4+/−) and in samples of human myocardium.MethodsWild-type (WT) and GPx4+/− mice were fed either a standard chow (CNTL) or HFHS diet for 24 weeks, with metabolic and cardiovascular parameters measured throughout. Biochemical and immuno-histological analysis was performed in heart and liver at termination of study, and mitochondrial function was analyzed in heart. Biochemical analysis was also performed on samples of human atrial myocardium from a cohort of 103 patients undergoing elective heart surgery.ResultsFollowing HFHS diet, WT mice displayed moderate increases in 4-hydroxynonenal (HNE)-adducts and carbonyl stress, and a 1.5-fold increase in GPx4 enzyme in both liver and heart, while gpx4 haploinsufficient (GPx4+/−) mice had marked carbonyl stress in these organs accompanied by exacerbated glucose intolerance, dyslipidemia, and liver steatosis. Although normotensive, cardiac hypertrophy was evident with obesity, and cardiac fibrosis more pronounced in obese GPx4+/− mice. Mitochondrial dysfunction manifesting as decreased fat oxidation capacity and increased reactive oxygen species was also present in obese GPx4+/− but not WT hearts, along with up-regulation of pro-inflammatory and pro-fibrotic genes. Patients with diabetes and hyperglycemia exhibited significantly less GPx4 enzyme and greater HNE-adducts in their hearts, compared with age-matched non-diabetic patients.ConclusionThese findings suggest LPPs are key factors underlying cardio-metabolic derangements that occur with obesity and that GPx4 serves a critical role as an adaptive countermeasure.

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Left ventricular diastolic function and cardiometabolic factors in obese normotensive children

Cited by 23 publications

References 28 publications

Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome

Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome

Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

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