Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies

Sciuk, Franziska; Vilsmaier, Theresa�; Kramer, Marie; Langer, Magdalena; Kolbinger, Brenda; Li, Pengzhu; Jakob, André; Rogenhofer, Nina; Dalla‐Pozza, Robert; Thaler, Christian J.; Haas, Nikolaus A.; Oberhoffer, Felix Sebastian

doi:10.3390/jcm11237128

Cited by 10 publications

(4 citation statements)

References 61 publications

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“…A recent study found lower LV systolic function in ART subjects compared to spontaneously conceived peers. However, after adjusting for birth weight percentiles and gestational age, M-mode-assessed LV systolic function showed no significant differences between the groups (21). Similarly, lower diastolic function in ART subjects was found in another study after adjusting for age, birth weight percentile, and gestational age (81), and there were no significant differences in LV diastolic function between the two groups.…”

Section: Cardiovascular Alterations Induced By Assisted Reproductive ...mentioning

confidence: 75%

Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

Li,

Liu,

Huang

et al. 2024

Front. Cardiovasc. Med.

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Recently, the use of assisted reproductive technology (ART) has rapidly increased. As a result, an increasing number of people are concerned about the safety of offspring produced through ART. Moreover, emerging evidence suggests an increased risk of cardiovascular disease (CVD) in offspring conceived using ART. In this review, we discuss the epigenetic mechanisms involved in altered DNA methylation, histone modification, and microRNA expression, as well as imprinting disorders. We also summarize studies on cardiovascular changes and other risk factors for cardiovascular disease, such as adverse intrauterine environments, perinatal complications, and altered metabolism following assisted reproductive technology (ART). Finally, we emphasize the epigenetic mechanisms underlying the increased risk of CVD in offspring conceived through ART, which could contribute to the early diagnosis and prevention of CVD in the ART population.

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Section: Cardiovascular Alterations Induced By Assisted Reproductive ...mentioning

confidence: 75%

Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

Li,

Liu,

Huang

et al. 2024

Front. Cardiovasc. Med.

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“…As this pilot study was part of the Munich heARTerY-study (assisted reproductive technologies and their effects on heart and arterial function in youth), inclusion and exclusion criteria focused primarily on the pediatric cohort [12][13][14][15][16]. To assess whether parents with history of ART displayed an increased cardiovascular morbidity, no exclusion criteria were applied for the parental cohort.…”

Section: Methodsmentioning

confidence: 99%

Vascular Health of Females with History of Assisted Reproductive Technology

Li,

Langer,

Vilsmaier

et al. 2024

JCDD

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The use of assisted reproductive technologies (ART) for the treatment of infertility is gaining popularity. Limited data on the overall vascular health of females with history of ART are available. This pilot study aimed to investigate the overall vascular health of females with history of ART compared to individuals who conceived spontaneously. The assessment of overall vascular health included the measurement of brachial blood pressure, central blood pressure, and pulse wave velocity, as well as the evaluation of the arterial stiffness and carotid intima-media thickness (cIMT) of the common carotid arteries. Conventional blood lipids including lipoprotein a (Lp(a)) were also determined. In total, 45 females with history of ART and 52 females who conceived spontaneously were included (mean age: 47.72 ± 5.96 years vs. 46.84 ± 7.43 years, p = 0.525). An initial comparison revealed a significantly higher prevalence of elevated Lp(a) in ART females (p = 0.011). However, after multiple comparison correction, the significant result disappeared (p = 0.132). Within the cohort of ART females, no significantly higher cardiovascular risk was detected regarding vascular function. The potentially higher prevalence of elevated Lp(a) in ART females must be further investigated in future studies, as it might contribute to the impaired reproductive process in this cohort.

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“…Для оцінки функції лівого шлуночка використовували парастернальні проекції по довгій і короткій осі та апікальні 2 -і 4-камерні проекції. Залежно від якості зображень ФВ ЛШ розраховували двовимірним методом (тобто Simpson) або методом M-mode (тобто Teichholtz) [23].…”

Section: навантажувальний тестunclassified

Heart Rate Variability During Physical Effort in Patients With Metastatic Ovarian Cancer and Concomitant Obesity

Yevsieieva,

Cherniy,

Kharchenko

et al. 2023

Clin. and prev. med.

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Introduction. One of the main factors affecting postoperative outcomes in patients with advanced ovarian cancer is the cardiopulmonary status. Several studies have reported that preoperative multifactorial rehabilitation and physical fitness can lead to reduced postoperative morbidity, mortality, shorter length of stay, and improved quality of life in cancer patients. The issue of adaptability to physical activity of overweight and obese patients who undergoing debulking surgery is insufficiently studied. The study of compensatory changes that occur in physically inactive obese patients remains relevant, especially against the background of neoadjuvant chemotherapy, in the conditions of preoperative preparation with ERAS-recommended physical activity. The aim of the study is to determine the differences between women with advanced ovarian cancer and obesity compared to women with normal weight in terms of heart rate variability during exercise. To assess the adaptive capabilities to physical activity of patients with advanced ovarian cancer and obesity at the stage of preoperative preparation, who undergoing debulking surgery. Result. Achieved METs, peak HR, CI, and HR recovery were higher in nonobese women, whereas training had no significant effect in obese women. Women who had already received neoadjuvant CT achieved a lower level of MET (6.8 ± 3.2 vs. 8.9 ± 4.1; P < 0.001). Also, peak HR and CI were lower in women after neoadjuvant CT (126±27 vs. 138±20; P = 0.001 and 0.65±0.22 vs. 0.71±0.22; P = 0.001, respectively). BMI was a significant predictor of exercise capacity only in the obese subgroup, whereas age, peak HR, and prior adjuvant HT were always significantly associated with METs achieved. Conclusions. No significant difference was found between trained and untrained women with comorbid obesity in HR behavior or physical capacity. Different heart rate behavior in patients of this group is thus explained by obesity as such, regardless of the degree of physical training.

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Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies

Cited by 10 publications

References 61 publications

Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

Vascular Health of Females with History of Assisted Reproductive Technology

Heart Rate Variability During Physical Effort in Patients With Metastatic Ovarian Cancer and Concomitant Obesity

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