Left ventricular diastolic performance in breast cancer survivors treated with anthracyclines

Rădulescu, Dan; Pripon, Sorin; Radulescu, Letitia I.; Duncea, Caius

doi:10.2143/ac.63.1.2025328

Cited by 11 publications

(4 citation statements)

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“…The A velocity reflects the active atrial contraction just before end-diastole and normally becomes more important in elderly patients, resulting in an E/A ratio approaching 1 [ 8 ]. However, a decreased E/A ratio could also imply diastolic dysfunction, indicating AIC, although opinions on the usefulness of the E/A ratio differ [ 4 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients

Bulten

Verberne

Bellersen

et al. 2015

Cancer Chemother Pharmacol

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Purpose It remains challenging to identify patients at risk of anthracycline-induced cardiotoxicity. To better understand the different risk-stratifying approaches, we evaluated 123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy and its interrelationship with conventional echocardiography, 2D strain imaging and several biomarkers.MethodsWe performed 123I-mIBG scintigraphy, conventional and strain echocardiography and biomarker (NT-proBNP, TNF-α, galectin-3, IL-6, troponin I, ST-2 and sFlt-1) assessment in 59 breast cancer survivors 1 year after anthracycline treatment. Interobserver and intermethod variability was calculated on planar and SPECT 123I-mIBG scintigraphy, using the heart/mediastinum (H/M) ratio and washout (WO). Pearson’s r and multivariate analyses were performed to identify correlations and independent predictors of 123I-mIBG scintigraphy results.ResultsDelayed planar anterior whole-heart ROI (WH) H/M ratios and WO were the most robust 123I-mIBG parameters. Significant correlations were observed between 123I-mIBG parameters and several conventional echo parameters, global longitudinal and radial strain (GLS and GRS) and galectin-3. The highest Pearson’s r was observed between delayed H/M ratio and GRS (Pearson’s r 0.36, p = 0.01). Multivariate analysis showed that GRS was the only independent predictor of the delayed WH H/M ratio (p = 0.023).ConclusionThe delayed planar H/M ratio is the most robust 123I-mIBG parameter. It correlates with several conventional echocardiographic parameters, GLS, GRS and galectin-3. Of these, only GRS predicts the H/M ratio.

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Section: Discussionmentioning

confidence: 99%

Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients

Bulten

Verberne

Bellersen

et al. 2015

Cancer Chemother Pharmacol

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“…(15, 16) Although some studies suggest that diastolic dysfunction may be an early sign of cardiotoxicity, the utility of diastolic function assessment during cancer treatment remains uncertain. (17, 18)…”

Section: Imaging For Early Detection Of Cardiotoxicitymentioning

confidence: 99%

Cardiomyopathy Associated With Cancer Therapy

Steingart

Fuster

2014

Journal of Cardiac Failure

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Chemotherapy associated cardiomyopathy is a well known cardiotoxicity of contemporary cancer treatment and a cause of increasing concern for both cardiologists and oncologists. As cancer outcomes improve, cardiovascular disease has become a leading cause of morbidity and mortality among cancer survivors. Asymptomatic or symptomatic left ventricular systolic dysfunction in the setting of cardiotoxic chemotherapy is an important entity to recognize. Early diagnosis of cardiac injury through the use of novel blood based biomarkers or noninvasive imaging modalities may allow for the initiation of cardioprotective medications or modification of chemotherapy regimen in order to minimize or prevent further damage. Several clinical trials are currently underway to determine the efficacy of cardioprotective medications for the prevention of chemotherapy associated cardiomyopathy. Implementing a strategy that includes both early detection and prevention of cardiotoxicity will likely have a significant impact on the overall prognosis of cancer survivors. Continued coordination of care between cardiologists and oncologists remains critical to maximizing the oncologic benefit of cancer therapy while minimizing any early or late cardiovascular effects.

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“…By using the trajectory γ * Before continuing, let us recall that the Local Inverse Function Theorem is also true for differentiable maps whose Jacobian determinant is always different from zero; see [3,19] and its references.…”

Section: Lemma 31 If Y Is As In Theorem a The Map Associated To Y mentioning

confidence: 99%

Center type performance of differentiable vector fields in the plane

Rabanal

2008

Proc. Amer. Math. Soc.

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Left ventricular diastolic performance in breast cancer survivors treated with anthracyclines

Cited by 11 publications

References 0 publications

Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients

Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients

Cardiomyopathy Associated With Cancer Therapy

Center type performance of differentiable vector fields in the plane

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